Twenty-five years ago, Hancock and Parks asked a provocative question:“what is the true
solubility advantage for amorphous pharmaceuticals?” Difficulties in determining the …

Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and
bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …

High drug load amorphous solid dispersions (ASDs) have been a challenge to formulate
partially because drug release is inhibited at high drug loads. The maximum drug load prior …

The in-situ formation of nanoparticles from polymer-based solid medicines, although
previously described, has been overlooked despite its potential to interfere with oral drug …

Polymers play an important role in amorphous solid dispersions (ASDs), enhancing stability
in the solid state and maintaining supersaturation in aqueous solutions of intrinsically low …

Cocrystallization and coamorphization are similar yet independent approaches toward
modifying various pharmaceutically relevant properties of modern drug compounds, in …

This study's integration of molecular dynamics (MD) simulations with non-covalent
adaptable networks (NANs) and corroborative wet lab experiments offers a comprehensive …

Nanodroplet formation is important to achieve supersaturation of active pharmaceutical
ingredients (APIs) in an amorphous solid dispersion. The aim of the current study was to …

Drug delivery systems utilizing the amorphous form of the drug are getting considerable
attention for improving the solubility and dissolution properties of poorly water-soluble drugs …

An ideal dissolution test for amorphous solid dispersions (ASDs) should reflect
physicochemical, physiological, and hydrodynamic conditions which accurately represent in …