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SARS‐CoV‐2, the pandemic coronavirus: Molecular and structural insights
The outbreak of a novel coronavirus associated with acute respiratory disease, called
COVID‐19, marked the introduction of the third spillover of an animal coronavirus (CoV) to …
COVID‐19, marked the introduction of the third spillover of an animal coronavirus (CoV) to …
RNA G-quadruplexes (rG4s): genomics and biological functions
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …
have been first observed decades ago. Over the years, these four-stranded structural motifs …
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have
devastating consequences worldwide. Recently, great efforts have been made to identify …
devastating consequences worldwide. Recently, great efforts have been made to identify …
Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19
SARS-CoV-2, the causative agent of COVID-19, remains among the main causes of global
mortality. Although antigen/antibody-based immunoassays and neutralizing antibodies …
mortality. Although antigen/antibody-based immunoassays and neutralizing antibodies …
Unlocking G-quadruplexes as antiviral targets
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
Predicting RNA structures and functions by artificial intelligence
RNA functions by interacting with its intended targets structurally. However, due to the
dynamic nature of RNA molecules, RNA structures are difficult to determine experimentally …
dynamic nature of RNA molecules, RNA structures are difficult to determine experimentally …
[HTML][HTML] G-quadruplex targeting in the fight against viruses: an update
G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of
key cellular processes, such as transcription and replication. Since their discovery, G4s have …
key cellular processes, such as transcription and replication. Since their discovery, G4s have …
Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), an epidemic disease characterized by rapid infection and a high …
disease 2019 (COVID-19), an epidemic disease characterized by rapid infection and a high …
[HTML][HTML] G-quadruplex-binding proteins: promising targets for drug design
G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with
the potential to form G4s are abundant in regulatory regions of the genome including …
the potential to form G4s are abundant in regulatory regions of the genome including …
RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models
G Qin, C Zhao, Y Liu, C Zhang, G Yang, J Yang… - Cell Discovery, 2022 - nature.com
The ongoing COVID-19 pandemic has continued to affect millions of lives worldwide,
leading to the urgent need for novel therapeutic strategies. G-quadruplexes (G4s) have …
leading to the urgent need for novel therapeutic strategies. G-quadruplexes (G4s) have …