Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease

D Goldblatt, G Alter, S Crotty… - Immunological Reviews, 2022 - Wiley Online Library
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …

Defining the risk of SARS-CoV-2 variants on immune protection

MM DeGrace, E Ghedin, MB Frieman, F Krammer… - Nature, 2022 - nature.com
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …

[HTML][HTML] mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

M Gagne, JI Moliva, KE Foulds, SF Andrew, BJ Flynn… - Cell, 2022 - cell.com
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to
neutralization following immunization with ancestral spike-matched vaccines. It is unclear …

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine–boosted nonhuman primates

KS Corbett, M Gagne, DA Wagner, S O'Connell… - Science, 2021 - science.org
Neutralizing antibody responses gradually wane against several variants of concern (VOCs)
after vaccination with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

SARS-CoV-2 mRNA vaccination elicits robust antibody responses in children

YC Bartsch, KJ St. Denis, P Kaplonek, J Kang… - Science translational …, 2022 - science.org
Although children have been largely spared from coronavirus disease 2019 (COVID-19), the
emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of …

Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB. 1.16 infection in nonhuman primates

M Gagne, BJ Flynn, SF Andrew, J Marquez… - Nature …, 2024 - nature.com
A mucosal route of vaccination could prevent severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We …

[HTML][HTML] Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

M Gagne, KS Corbett, BJ Flynn, KE Foulds, DA Wagner… - Cell, 2022 - cell.com
Summary mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time;
however, there are limited data on the impact of durability of immune responses on …

The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants

M Koutsakos, WS Lee, A Reynaldi, HX Tan, G Gare… - Immunity, 2022 - cell.com
Vaccination against SARS-CoV-2 protects from infection and improves clinical outcomes in
breakthrough infections, likely reflecting residual vaccine-elicited immunity and recall of …

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

EG Viox, TN Hoang, AA Upadhyay, R Nchioua… - Science …, 2023 - science.org
Type I interferons (IFN-I) are critical mediators of innate control of viral infections but also
drive the recruitment of inflammatory cells to sites of infection, a key feature of severe …

COVID-19 vaccines: current and future perspectives

L Soraci, F Lattanzio, G Soraci, ME Gambuzza… - Vaccines, 2022 - mdpi.com
Currently available vaccines against severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) are highly effective but not able to keep the coronavirus disease 2019 …