Animals rely on their nervous systems to process sensory inputs, integrate these with
internal signals, and produce behavioral outputs. This is enabled by the highly specialized …

Phasic (fast) and tonic (sustained) inhibition of γ-aminobutyric acid (GABA) are fundamental
for regulating day-to-day activities, neuronal excitability, and plasticity. However, the …

Myosin storage myopathy (MSM) is a rare skeletal muscle disorder caused by mutations in
the slow muscle/β-cardiac myosin heavy chain (MHC) gene. MSM missense mutations …

During development, animals can maintain behavioral output even as underlying circuitry
structurally remodels. After hatching, C. elegans undergoes substantial motor neuron …

Adult animals display robust locomotion, yet the timeline and mechanisms of how juvenile
animals acquire coordinated movements and how these movements evolve during …

There are many theories of how behavior may be controlled by neurons. Testing and
refining these theories would be greatly facilitated if we could correctly simulate an entire …

Genetically encoded optical indicators and actuators of neural activity allow for all-optical
investigations of signaling in the nervous system. But commonly used indicators, actuators …

To understand the function of cells such as neurons within an organism, it can be
instrumental to inhibit cellular function, or to remove the cell (type) from the organism, and …

Cryptococcus neoformans is an opportunistic fungal pathogen with a polysaccharide
capsule that becomes greatly enlarged in the mammalian host and during in vitro growth …

Continuity of behaviors requires animals to make smooth transitions between mutually
exclusive behavioral states. Neural principles that govern these transitions are not well …