Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Amyloid-type protein aggregation and prion-like properties of amyloids
This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …
an important hallmark of protein misfolding diseases and therefore have been investigated …
Congo Red and amyloids: history and relationship
EI Yakupova, LG Bobyleva, IM Vikhlyantsev… - Bioscience …, 2019 - portlandpress.com
Abstract Staining with Congo Red (CR) is a qualitative method used for the identification of
amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained …
amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained …
Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils
Amyloid-β (Aβ) is a 39–42 residue protein produced by the cleavage of the amyloid
precursor protein (APP), which subsequently aggregates to form cross-β amyloid fibrils that …
precursor protein (APP), which subsequently aggregates to form cross-β amyloid fibrils that …
Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
[HTML][HTML] Molecular structure of β-amyloid fibrils in Alzheimer's disease brain tissue
JX Lu, W Qiang, WM Yau, CD Schwieters, SC Meredith… - Cell, 2013 - cell.com
In vitro, β-amyloid (Aβ) peptides form polymorphic fibrils, with molecular structures that
depend on growth conditions, plus various oligomeric and protofibrillar aggregates. Here …
depend on growth conditions, plus various oligomeric and protofibrillar aggregates. Here …
The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization
IW Hamley - Chemical reviews, 2012 - ACS Publications
This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
[HTML][HTML] Amyloid polymorphism: structural basis and neurobiological relevance
R Tycko - Neuron, 2015 - cell.com
Our understanding of the molecular structures of amyloid fibrils that are associated with
neurodegenerative diseases, of mechanisms by which disease-associated peptides and …
neurodegenerative diseases, of mechanisms by which disease-associated peptides and …
[HTML][HTML] Infrared spectroscopy of proteins
A Barth - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2007 - Elsevier
Infrared spectroscopy of proteins - ScienceDirect Skip to main contentSkip to article Elsevier
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What vibrations tell about proteins
A Barth, C Zscherp - Quarterly reviews of biophysics, 2002 - cambridge.org
1. Introduction 3702. Infrared (IR) spectroscopy–general principles 3722.1 Vibrations 3722.2
Information that can be derived from the vibrational spectrum 3722.3 Absorption of IR light …
Information that can be derived from the vibrational spectrum 3722.3 Absorption of IR light …