Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
Arylamine N‐acetyltransferases (NAT s) are polymorphic drug‐metabolizing enzymes,
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …
New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics
E Jeffrey North, M Jackson… - Current pharmaceutical …, 2014 - ingentaconnect.com
Mycolic acids are the major lipid components of the unique mycobacterial cell wall
responsible for the protection of the tuberculosis bacilli from many outside threats. Mycolic …
responsible for the protection of the tuberculosis bacilli from many outside threats. Mycolic …
Terminalia laxiflora and Terminalia brownii contain a broad spectrum of antimycobacterial compounds including ellagitannins, ellagic acid derivatives, triterpenes, fatty …
EYA Salih, R Julkunen-Tiitto, AM Lampi… - Journal of …, 2018 - Elsevier
Abstract Ethnopharmacological relevance Terminalia laxiflora Engl. & Diels,(Sudanese
Arabic name: Darout الدروت) and Terminalia brownii Fresen (Sudanese Arabic name: Alshaf …
Arabic name: Darout الدروت) and Terminalia brownii Fresen (Sudanese Arabic name: Alshaf …
Cholesterol metabolism: a potential therapeutic target in Mycobacteria
A Abuhammad - British journal of pharmacology, 2017 - Wiley Online Library
Tuberculosis (TB), although a curable disease, is still one of the most difficult infections to
treat. Mycobacterium tuberculosis infects 10 million people worldwide and kills 1.5 million …
treat. Mycobacterium tuberculosis infects 10 million people worldwide and kills 1.5 million …
[HTML][HTML] Organic Sunscreens—Is Their Placenta Permeability the Only Issue Associated with Exposure During Pregnancy? In Silico Studies of Sunscreens' Placenta …
AW Sobańska, AM Sobański - Molecules, 2024 - mdpi.com
One of the functions of placenta is to protect the fetus against harmful xenobiotics. Protective
mechanisms of placenta are based on enzymes, eg, antioxidant enzymes from the …
mechanisms of placenta are based on enzymes, eg, antioxidant enzymes from the …
Mycobacterium tuberculosis Acetyltransferase Suppresses Oxidative Stress by Inducing Peroxisome Formation in Macrophages
A Behera, P Jain, G Ganguli, M Biswas… - International Journal of …, 2022 - mdpi.com
Mycobacterium tuberculosis (Mtb) inhibits host oxidative stress responses facilitating its
survival in macrophages; however, the underlying molecular mechanisms are poorly …
survival in macrophages; however, the underlying molecular mechanisms are poorly …
Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over …
Arylamine N-acetyltransferase from Mycobacterium tuberculosis (TBNAT) plays an important
role in the intracellular survival of the microorganism inside macrophages. Medicinal …
role in the intracellular survival of the microorganism inside macrophages. Medicinal …
A Microbiological, Toxicological, and Biochemical Study of the Effects of Fucoxanthin, a Marine Carotenoid, on Mycobacterium tuberculosis and the Enzymes …
M Šudomová, MA Shariati, J Echeverría… - Marine drugs, 2019 - mdpi.com
This study explored the antitubercular properties of fucoxanthin, a marine carotenoid,
against clinical isolates of Mycobacterium tuberculosis (Mtb). Two vital enzymes involved in …
against clinical isolates of Mycobacterium tuberculosis (Mtb). Two vital enzymes involved in …
Design, synthesis and structure–activity relationships of 3, 5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase
The synthesis and inhibitory potencies of a novel series of 3, 5-diaryl-1H-pyrazoles as
specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The …
specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The …