Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy,
clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS …

Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term
maintenance. The common feature of this altered metabolism is the increased glucose …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …

Transformed cells adapt metabolism to support tumor initiation and progression. Specific
metabolic activities can participate directly in the process of transformation or support the …

Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …

Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …