Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …

Diffusion MRI (dMRI) has proven to be a useful imaging approach for both clinical diagnosis
and research investigating the microstructures of nervous tissues, and it has helped us to …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest
sites of tauopathy in Alzheimer's disease (AD). They project broadly throughout the brain's …

Background Diffusion imaging holds great potential for the non‐invasive assessment of the
glymphatic system in humans. One technique, diffusion tensor imaging along the …

There has been an increasing prevalence of neurodegenerative diseases with the rapid
increase in aging societies worldwide. Biomarkers that can be used to detect pathological …

Neuroinflammation contributes to the pathology and progression of Alzheimer's disease
(AD), and it can be observed even with mild cognitive impairment (MCI), a prodromal phase …

Background Mild behavioral impairment (MBI) is a syndrome that uses later‐life emergent
and persistent neuropsychiatric symptoms (NPS) to identify a group at high risk for incident …