The role of oxidative stress in Parkinson's disease
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …
Molecular pathophysiology of Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
KA Conway, JC Rochet, RM Bieganski, PT Lansbury Jr - Science, 2001 - science.org
The substantia nigra in Parkinson's disease (PD) is depleted of dopaminergic neurons and
contains fibrillar Lewy bodies comprising primarily α-synuclein. We screened a library to …
contains fibrillar Lewy bodies comprising primarily α-synuclein. We screened a library to …
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
Expanding insights of mitochondrial dysfunction in Parkinson's disease
The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily
influenced by the genes associated with the disease. The α-synuclein-centric theory of …
influenced by the genes associated with the disease. The α-synuclein-centric theory of …
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
AHV Schapira - The Lancet Neurology, 2008 - thelancet.com
Several biochemical abnormalities have been described in the brains of patients with
Parkinson's disease (PD), including oxidative stress and mitochondrial dysfunction. The …
Parkinson's disease (PD), including oxidative stress and mitochondrial dysfunction. The …
Parkinson-like neurodegeneration induced by targeted overexpression of α-synuclein in the nigrostriatal system
Recombinant adeno-associated viral vectors display efficient tropism for transduction of the
dopamine neurons of the substantia nigra. Taking advantage of this unique property of …
dopamine neurons of the substantia nigra. Taking advantage of this unique property of …
[HTML][HTML] Mitochondrial dysfunction in Parkinson's disease
KF Winklhofer, C Haass - Biochimica et Biophysica Acta (BBA)-Molecular …, 2010 - Elsevier
Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …
their prominent role in energy metabolism, mitochondria are intimately involved in various …
Dopamine-dependent neurotoxicity of α-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
The mechanism by which dopaminergic neurons are selectively lost in Parkinson disease
(PD) is unknown. Here we show that accumulation of α-synuclein in cultured human …
(PD) is unknown. Here we show that accumulation of α-synuclein in cultured human …
Oxidative stress and nitration in neurodegeneration: cause, effect, or association?
H Ischiropoulos, JS Beckman - The Journal of clinical …, 2003 - Am Soc Clin Investig
(ALS); manganese superoxide dismutase (Mn-SOD); Cu/Zn superoxide dismutase (Cu/Zn-
SOD); hypochlorous acid (HOCl); nitric oxide synthase (NOS); 1-methyl-4-phenyl-1, 2, 3, 6 …
SOD); hypochlorous acid (HOCl); nitric oxide synthase (NOS); 1-methyl-4-phenyl-1, 2, 3, 6 …