Establishing outcome measures in early knee osteoarthritis

CA Emery, JL Whittaker, A Mahmoudian… - Nature Reviews …, 2019 - nature.com
The classification and monitoring of individuals with early knee osteoarthritis (OA) are
important considerations for the design and evaluation of therapeutic interventions and …

Machine learning methods to support personalized neuromusculoskeletal modelling

DJ Saxby, BA Killen, C Pizzolato, CP Carty… - … and Modeling in …, 2020 - Springer
Many biomedical, orthopaedic, and industrial applications are emerging that will benefit from
personalized neuromusculoskeletal models. Applications include refined diagnostics …

The future of in-field sports biomechanics: wearables plus modelling compute real-time in vivo tissue loading to prevent and repair musculoskeletal injuries

D Lloyd - Sports Biomechanics, 2024 - Taylor & Francis
This paper explores the use of biomechanics in identifying the mechanistic causes of
musculoskeletal tissue injury and degeneration. It appraises how biomechanics has been …

[PDF][PDF] Non-pharmacological and non-surgical interventions for knee osteoarthritis: a systematic review and meta-analysis

RM Ferreira, RT Torres, JA Duarte… - Acta Reumatol …, 2019 - researchgate.net
Artigo original 1. physical education and sports department, N2i, institute polytechnic of maia
2. faculty of sport, ciafel, university of porto 3. cespu, North institute polytechnic of Health 4 …

MyoSim: Fast and physiologically realistic MuJoCo models for musculoskeletal and exoskeletal studies

H Wang, V Caggiano, G Durandau… - … on Robotics and …, 2022 - ieeexplore.ieee.org
Owing to the restrictions of live experimentation, musculoskeletal simulation models play a
key role in biological motor control studies and investigations. Successful results of which …

[HTML][HTML] Osteoarthritis year in review 2016: mechanics

DJ Saxby, DG Lloyd - Osteoarthritis and cartilage, 2017 - Elsevier
Inappropriate biomechanics, namely wear-and-tear, has been long believed to be a main
cause of osteoarthritis (OA). However, this view is now being re-evaluated, especially when …

A novel mechanobiological model can predict how physiologically relevant dynamic loading causes proteoglycan loss in mechanically injured articular cartilage

GA Orozco, P Tanska, C Florea, AJ Grodzinsky… - Scientific reports, 2018 - nature.com
Cartilage provides low-friction properties and plays an essential role in diarthrodial joints. A
hydrated ground substance composed mainly of proteoglycans (PGs) and a fibrillar collagen …

Hip joint mechanics during walking in individuals with mild-to-moderate hip osteoarthritis

M Constantinou, A Loureiro, C Carty, P Mills, R Barrett - Gait & posture, 2017 - Elsevier
The purpose of this case-control study was to characterise hip joint kinematics and moments
during gait in people with mild-to-moderate hip osteoarthritis (OA). Eligible participants were …

High tibiofemoral contact and muscle forces during gait are associated with radiographic knee OA progression over 3 years

P Amiri, EM Davis, J Outerleys, RH Miller, S Brandon… - The knee, 2023 - Elsevier
Background The objective of this study was to investigate differences in tibiofemoral joint
contact forces between individuals with moderate medial OA who exhibit radiographic knee …

New algorithm for simulation of proteoglycan loss and collagen degeneration in the knee joint: data from the osteoarthritis initiative

ME Mononen, P Tanska, H Isaksson… - Journal of …, 2018 - Wiley Online Library
Osteoarthritis is a harmful joint disease but prediction of disease progression is problematic.
Currently, there is only one modeling framework which can be applied to predict the …