Ubiquitylation is an emerging mechanism implicated in a variety of nonproteolytic cellular
functions. The attachment of a single ubiquitin (Ub) or poly‐Ub (lysine 63) chains to proteins …

Ubiquitin is best known for its function in targeting proteins for degradation by the
proteasome. Recent studies have revealed several new functions of ubiquitin that are …

Inhibition of PARP is a promising therapeutic strategy for homologous recombination–
deficient tumors, such as BRCA1-associated cancers. We previously reported that BRCA1 …

The cellular response to highly genotoxic DNA double-strand breaks (DSBs) involves the
exquisite coordination of multiple signaling and repair factors. Here, we conducted a …

Fanconi anemia is a recessively inherited disease characterized by congenital defects, bone
marrow failure and cancer susceptibility,. Cells from individuals with Fanconi anemia are …

Hereditary breast cancers are frequently caused by germline BRCA1 mutations. The BRCA1
C61G mutation in the BRCA1 RING domain is a common pathogenic missense variant …

Mutations in any of at least sixteen FANC genes (FANCA–Q) cause Fanconi anemia, a
disorder characterized by sensitivity to DNA interstrand crosslinking agents. The clinical …

Over the past few years, study of the rare inherited chromosome instability disorder, Fanconi
Anemia (FA), has uncovered a novel DNA damage response pathway. Through the …

We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also
known as BRIP1, failed to elicit homologous recombination (HR) after DNA double-stranded …

A rare genetic disease, Fanconi anemia (FA), now attracts broader attention from cancer
biologists and basic researchers in the DNA repair and ubiquitin biology fields as well as …