The expanding world of tRNA modifications and their disease relevance
T Suzuki - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …
tRNA therapeutics for genetic diseases
J Coller, Z Ignatova - Nature Reviews Drug Discovery, 2024 - nature.com
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their
therapeutic potential for the treatment of genetic diseases—primarily those associated with a …
therapeutic potential for the treatment of genetic diseases—primarily those associated with a …
Engineered tRNAs suppress nonsense mutations in cells and in vivo
Nonsense mutations are the underlying cause of approximately 11% of all inherited genetic
diseases. Nonsense mutations convert a sense codon that is decoded by tRNA into a …
diseases. Nonsense mutations convert a sense codon that is decoded by tRNA into a …
Transfer RNA modifications and cellular thermotolerance
T Ohira, T Suzuki - Molecular Cell, 2024 - cell.com
RNA molecules are modified post-transcriptionally to acquire their diverse functions.
Transfer RNA (tRNA) has the widest variety and largest numbers of RNA modifications …
Transfer RNA (tRNA) has the widest variety and largest numbers of RNA modifications …
Translation velocity determines the efficacy of engineered suppressor tRNAs on pathogenic nonsense mutations
N Bharti, L Santos, M Davyt, S Behrmann… - Nature …, 2024 - nature.com
Nonsense mutations–the underlying cause of approximately 11% of all genetic diseases–
prematurely terminate protein synthesis by mutating a sense codon to a premature stop or …
prematurely terminate protein synthesis by mutating a sense codon to a premature stop or …
Repurposing tRNAs for nonsense suppression
Three stop codons (UAA, UAG and UGA) terminate protein synthesis and are almost
exclusively recognized by release factors. Here, we design de novo transfer RNAs (tRNAs) …
exclusively recognized by release factors. Here, we design de novo transfer RNAs (tRNAs) …
Ribosomal incorporation of negatively charged d-α- and N-methyl-l-α-amino acids enhanced by EF-Sep
T Katoh, H Suga - … Transactions of the Royal Society B, 2023 - royalsocietypublishing.org
Ribosomal incorporation of d-α-amino acids (dAA) and N-methyl-l-α-amino acids (MeAA)
with negatively charged sidechains, such as d-Asp, d-Glu, MeAsp and MeGlu, into nascent …
with negatively charged sidechains, such as d-Asp, d-Glu, MeAsp and MeGlu, into nascent …
Expansion of the genetic code through reassignment of redundant sense codons using fully modified tRNA
CAL McFeely, KK Dods, SS Patel… - Nucleic Acids …, 2022 - academic.oup.com
Breaking codon degeneracy for the introduction of non-canonical amino acids offers many
opportunities in synthetic biology. Yet, despite the existence of 64 codons, the code has only …
opportunities in synthetic biology. Yet, despite the existence of 64 codons, the code has only …
Tuning tRNAs for improved translation
JL Weiss, JC Decker, A Bolano, N Krahn - Frontiers in Genetics, 2024 - frontiersin.org
Transfer RNAs have been extensively explored as the molecules that translate the genetic
code into proteins. At this interface of genetics and biochemistry, tRNAs direct the efficiency …
code into proteins. At this interface of genetics and biochemistry, tRNAs direct the efficiency …
Posttranscriptional modification to the core of tRNAs modulates translational misreading errors
S Saleh, PJ Farabaugh - RNA, 2024 - rnajournal.cshlp.org
Protein synthesis on the ribosome involves successive rapid recruitment of cognate
aminoacyl-tRNAs and rejection of the much more numerous incorrect near-or non-cognates …
aminoacyl-tRNAs and rejection of the much more numerous incorrect near-or non-cognates …