The genetics of asthma and allergic disease: a 21st century perspective

C Ober, TC Yao - Immunological reviews, 2011 - Wiley Online Library
Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …

Discovering susceptibility genes for asthma and allergy

D Vercelli - Nature reviews immunology, 2008 - nature.com
Asthma and asthma-related traits are complex diseases with strong genetic and
environmental components. Rapid progress in asthma genetics has led to the identification …

A large-scale, consortium-based genomewide association study of asthma

MF Moffatt, IG Gut, F Demenais… - … England Journal of …, 2010 - Mass Medical Soc
Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …

Asthma genetics 2006: the long and winding road to gene discovery

C Ober, S Hoffjan - Genes & Immunity, 2006 - nature.com
Asthma and atopy are complex phenotypes that are influenced by both genetic and
environmental factors. A review of nearly 500 papers on disease association studies …

The regulation of immunoglobulin E class-switch recombination

RS Geha, HH Jabara, SR Brodeur - Nature Reviews Immunology, 2003 - nature.com
Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely
allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence …

Update on glucocorticoid action and resistance

K Ito, KF Chung, IM Adcock - Journal of Allergy and Clinical Immunology, 2006 - Elsevier
Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

The Ashbya gossypii Genome as a Tool for Map** the Ancient Saccharomyces cerevisiae Genome

FS Dietrich, S Voegeli, S Brachat, A Lerch, K Gates… - Science, 2004 - science.org
We have sequenced and annotated the genome of the filamentous ascomycete Ashbya
gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the …

Genetics of allergic disease

JW Holloway, IA Yang, ST Holgate - Journal of Allergy and Clinical …, 2010 - Elsevier
Allergic diseases are complex genetic diseases resulting from the effect of multiple genetic
and interacting environmental factors on their pathophysiology. Recent years have seen …

Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions

X Li, TD Howard, SL Zheng, T Haselkorn… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Asthma is a heterogeneous disease that is caused by the interaction of
genetic susceptibility with environmental influences. Genome-wide association studies …

Characterization of a common susceptibility locus for asthma-related traits

T Laitinen, A Polvi, P Rydman, J Vendelin, V Pulkkinen… - Science, 2004 - science.org
Susceptibility to asthma depends on variation at an unknown number of genetic loci. To
identify susceptibility genes on chromosome 7p, we adopted a hierarchical genoty** …