The genetics of asthma and allergic disease: a 21st century perspective
Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …
and environmental contributions. Recent genome‐wide association studies (GWAS) and …
Discovering susceptibility genes for asthma and allergy
D Vercelli - Nature reviews immunology, 2008 - nature.com
Asthma and asthma-related traits are complex diseases with strong genetic and
environmental components. Rapid progress in asthma genetics has led to the identification …
environmental components. Rapid progress in asthma genetics has led to the identification …
A large-scale, consortium-based genomewide association study of asthma
Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …
Asthma genetics 2006: the long and winding road to gene discovery
C Ober, S Hoffjan - Genes & Immunity, 2006 - nature.com
Asthma and atopy are complex phenotypes that are influenced by both genetic and
environmental factors. A review of nearly 500 papers on disease association studies …
environmental factors. A review of nearly 500 papers on disease association studies …
The regulation of immunoglobulin E class-switch recombination
RS Geha, HH Jabara, SR Brodeur - Nature Reviews Immunology, 2003 - nature.com
Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely
allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence …
allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence …
Update on glucocorticoid action and resistance
Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …
molecules that have been optimized to target activity to the lung and minimize systemic …
The Ashbya gossypii Genome as a Tool for Map** the Ancient Saccharomyces cerevisiae Genome
We have sequenced and annotated the genome of the filamentous ascomycete Ashbya
gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the …
gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the …
Genetics of allergic disease
Allergic diseases are complex genetic diseases resulting from the effect of multiple genetic
and interacting environmental factors on their pathophysiology. Recent years have seen …
and interacting environmental factors on their pathophysiology. Recent years have seen …
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions
X Li, TD Howard, SL Zheng, T Haselkorn… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Asthma is a heterogeneous disease that is caused by the interaction of
genetic susceptibility with environmental influences. Genome-wide association studies …
genetic susceptibility with environmental influences. Genome-wide association studies …
Characterization of a common susceptibility locus for asthma-related traits
T Laitinen, A Polvi, P Rydman, J Vendelin, V Pulkkinen… - Science, 2004 - science.org
Susceptibility to asthma depends on variation at an unknown number of genetic loci. To
identify susceptibility genes on chromosome 7p, we adopted a hierarchical genoty** …
identify susceptibility genes on chromosome 7p, we adopted a hierarchical genoty** …