Appropriate mitochondrial physiology is an essential for health and survival. Cells have
developed unique mechanisms to adapt to stress circumstances and changes in metabolic …

Diet might affect male reproductive potential, but the biochemical mechanisms involved in
the modulation of sperm quality remain poorly understood. While a Western diet is …

Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐
inflammatory senescence‐associated secretory phenotype (SASP), which is a major …

Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and
oxidative stress have been greatly implicated in the progression of aging, along with the …

Osteoarthritis (OA) is a progressive joint disorder that is primarily characterized by the
degeneration and destruction of the articular cartilage. Cartilage matrix degradation …

Ferroptosis, a novel form of regulated cell death, is caused by accumulation of lipid
peroxides and excessive iron deposition. This process has been linked to the death of …

Quercetin belongs to the flavonoids family, which is present in most of the plants including
fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available …

Apoptosis of chondrocytes are the main initiator of osteoarthritis (OA) and can be explained
by oxidative stress and endoplasmic reticulum (ER) stress, thus the pharmacological …

The maintenance of cellular function relies on the close regulation of adenosine
triphosphate (ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase …

The flavonoid quercetin (3, 3′, 4′, 5, 7-pentahydroxyflavone) is widely distributed in
plants, foods, and beverages. This polyphenol compound exhibits varied biological actions …