How far are non-viral vectors to come of age and reach clinical translation in gene therapy?
M Sainz-Ramos, I Gallego, I Villate-Beitia… - International Journal of …, 2021 - mdpi.com
Efficient delivery of genetic material into cells is a critical process to translate gene therapy
into clinical practice. In this sense, the increased knowledge acquired during past years in …
into clinical practice. In this sense, the increased knowledge acquired during past years in …
Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and …
G Gauglitz - Analytical and Bioanalytical Chemistry, 2020 - Springer
Direct optical detection has proven to be a highly interesting tool in biomolecular interaction
analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis …
analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis …
Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: A crystallographic, kinetic and calorimetric study
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the
neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic …
neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic …
[HTML][HTML] Overview of the detection methods for equilibrium dissociation constant KD of drug-receptor interaction
W Ma, L Yang, L He - Journal of pharmaceutical analysis, 2018 - Elsevier
Drug-receptor interaction plays an important role in a series of biological effects, such as cell
proliferation, immune response, tumor metastasis, and drug delivery. Therefore, the …
proliferation, immune response, tumor metastasis, and drug delivery. Therefore, the …
Assays and technologies for develo** proteolysis targeting chimera degraders
Targeted protein degradation by small-molecule degraders represents an emerging mode of
action in drug discovery. Proteolysis targeting chimeras (PROTACs) are small molecules …
action in drug discovery. Proteolysis targeting chimeras (PROTACs) are small molecules …
Uncertainty in protein–ligand binding constants: asymmetric confidence intervals versus standard errors
Equilibrium binding constants (K b) between chemical compounds and target proteins or
between interacting proteins provide a quantitative understanding of biological interaction …
between interacting proteins provide a quantitative understanding of biological interaction …
Combined NMR and Isothermal Titration Calorimetry Investigation Resolves Conditions for Ligand Exchange and Phase Transformation in CsPbBr3 Nanocrystals
SL Abiodun, MY Gee, AB Greytak - The Journal of Physical …, 2021 - ACS Publications
Inorganic halide perovskite nanocrystals (NCs), such as CsPbBr3 quantum dots, have
emerged as an intriguing alternative to traditional semiconductors in optoelectronic devices …
emerged as an intriguing alternative to traditional semiconductors in optoelectronic devices …
Applications of isothermal titration calorimetry in pure and applied research from 2016 to 2020
The last 5 years have seen a series of advances in the application of isothermal titration
microcalorimetry (ITC) and interpretation of ITC data. ITC has played an invaluable role in …
microcalorimetry (ITC) and interpretation of ITC data. ITC has played an invaluable role in …
Isothermal titration calorimetry resolves sequential ligand exchange and association reactions in treatment of oleate-capped CdSe quantum dots with alkylphosphonic …
MY Gee, Y Shen, AB Greytak - The Journal of Physical Chemistry …, 2020 - ACS Publications
This article examines a prototypical nanocrystal surface reaction, the replacement of
carboxylate ligands with alkylphosphonate on CdSe quantum dots (QDs), in an anhydrous …
carboxylate ligands with alkylphosphonate on CdSe quantum dots (QDs), in an anhydrous …
Rational design of thermodynamic and kinetic binding profiles by optimizing surface water networks coating protein-bound ligands
A previously studied congeneric series of thermolysin inhibitors addressing the solvent-
accessible S2′ pocket with different hydrophobic substituents showed modulations of the …
accessible S2′ pocket with different hydrophobic substituents showed modulations of the …