Abstract In 1989, Manning, Patel, and Borchardt wrote a review of protein stability (Manning
et al., Pharm. Res. 6: 903–918, 1989), which has been widely referenced ever since. At the …

Paleontology, archeology, and art history provide crucial information for the understanding
of human evolution throughout ages and its habits. Past animal and plant species are also …

For about three decades, the chemistry of cation radicals derived from organic molecules
had received a major impetus from mass spectrometry. This was because cation radicals …

The current status of de novo sequencing of peptides by MS/MS is reviewed with focus on
collision cell MS/MS spectra. The relation between peptide structure and observed fragment …

One of the most frequent modifications in proteins and peptides is the deamidation of
asparagine, a spontaneous non‐enzymatic reaction leading to a mixture of l, d‐succinimidyl …

Untitled Page 1 Page 2 Reiner Westermeier, Tom Naven, and Hans-Rudolf Hçpker Proteomics
in Practice Proteomics in Practice. A Guide to Successful Experimental Design 2nd Ed. Reiner …

Background The development of lethal cancer metastasis depends on the dynamic
interactions between cancer cells and the tumor microenvironment, both of which are …

In recent years, electron capture (ECD) and electron transfer dissociation (ETD) have
emerged as two of the most useful methods in mass spectrometry‐based protein analysis …

Identification of deamidated sites in proteins is commonly used for assignment of N-
glycosylation sites. It is also important for assessing the role of deamidation in vivo …

Mass spectrometry has rapidly evolved to become the platform of choice for proteomic
analysis. While CID remains the major fragmentation method for peptide sequencing …