Abstract Interleukin-2 (IL-2) signals influence various lymphocyte subsets during
differentiation, immune responses and homeostasis. As discussed in this Review …

Abstract Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central
role in infection by limiting the immune response to pathogens and thereby preventing …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

β‐glucans are recognized by the innate immune system. This recognition plays important
roles in host defense and presents specific opportunities for clinical modulation of the host …

The innate immune response was once considered to be a limited set of responses that
aimed to contain an infection by primitive'ingest and kill'mechanisms, giving the host time to …

Myeloid cells are key drivers of physiological responses to pathogen invasion or tissue
damage. Members of the C-type lectin receptor (CLR) family stand out among the …

C-type lectin receptors (CLRs) comprise a heterogeneous group of transmembrane proteins.
Many of them are expressed in myeloid cells and signal in response to pathogen-derived or …

Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which
signal for initiation of immune responses to infection. Studies with Dectin-1, a PRR for fungi …

Neuroimmune diseases have diverse symptoms and etiologies but all involve pathological
inflammation that affects normal central nervous system signaling. Critically, many …

The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway mediates
multiple adaptive T-cell functions, but recent studies have shown that calcineurin/NFAT …