Pathogenesis of antiphospholipid syndrome: understanding the antibodies

PL Meroni, MO Borghi, E Raschi… - Nature Reviews …, 2011 - nature.com
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …

[HTML][HTML] Seronegative antiphospholipid syndrome: refining the value of “non-criteria” antibodies for diagnosis and clinical management

P Pignatelli, E Ettorre, D Menichelli, A Pani, F Violi… - …, 2020 - ncbi.nlm.nih.gov
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by
arterial and venous thrombotic manifestations and/or pregnancy-related complications in …

GAPSS: the global anti-phospholipid syndrome score

S Sciascia, G Sanna, V Murru, D Roccatello… - …, 2013 - academic.oup.com
Objective. To develop and validate a risk score [global APS score (GAPSS)] derived from the
combination of independent risk for thrombosis and pregnancy loss (PL), taking into account …

Anti-prothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome

S Sciascia, G Sanna, V Murru… - Thrombosis and …, 2014 - thieme-connect.com
Antibodies to prothrombin are detected by directly coating prothrombin on irradiated ELISA
plates (aPT) or by using the phosphatidylserine/prothrombin complex as antigen (aPS/PT) …

14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

ML Bertolaccini, O Amengual, L Andreoli, T Atsumi… - Autoimmunity …, 2014 - Elsevier
Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use
of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in …

'Non-criteria'aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, USA, April …

ML Bertolaccini, O Amengual, T Atsumi, WL Binder… - Lupus, 2011 - journals.sagepub.com
Current classification criteria for definite APS recommend the use of one or more of three
positive standardized laboratory assays, including anticardiolipin antibodies (aCL), lupus …

The global anti-phospholipid syndrome score in primary APS

S Sciascia, G Sanna, V Murru, D Roccatello… - …, 2015 - academic.oup.com
Objective. The aim of this study was to evaluate the clinical relevance of the global APS
score (GAPSS) in a cohort of primary APS patients. Methods. This study included 62 …

Antiphospholipid syndrome and recurrent miscarriage: A systematic review and meta-analysis

T da Silva Santos, AL Ieque, HC de Carvalho… - Journal of reproductive …, 2017 - Elsevier
Antiphospholipid syndrome (APS) is an autoimmune condition that is associated with
thrombosis and morbidity in pregnancy. The exact mechanisms by which these associations …

Antiphosphatidylserine/prothrombin antibodies: an update on their association with clinical manifestations of antiphospholipid syndrome

M Radin, SG Foddai, I Cecchi, E Rubini… - Thrombosis and …, 2020 - thieme-connect.com
Objective The aim of the study is to perform a systematic review on the recent available
evidence on antiphosphatidylserine/prothrombin (aPS/PT) antibodies and their association …

Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers

PL Meroni, CB Chighizola, F Rovelli… - Arthritis research & …, 2014 - Springer
The clinical spectrum of the anti-phospholipid syndrome (APS) is not limited to vascular
thrombosis or miscarriages but includes additional manifestations that cannot be explained …