Classification and staging of Parkinson's disease using video-based eye tracking

DC Brien, HC Riek, R Yep, J Huang, B Coe… - Parkinsonism & Related …, 2023 - Elsevier
Introduction 83% of those diagnosed with Parkinson's Disease (PD) eventually progress to
PD with mild cognitive impairment (PD-MCI) followed by dementia (PDD)-suggesting a …

What is a blink? Classifying and characterizing blinks in eye openness signals

M Nyström, R Andersson, DC Niehorster… - Behavior research …, 2024 - Springer
Blinks, the closing and opening of the eyelids, are used in a wide array of fields where
human function and behavior are studied. In data from video-based eye trackers, blink rate …

Interleaved pro/anti-saccade behavior across the lifespan

R Yep, ML Smorenburg, HC Riek… - Frontiers in aging …, 2022 - frontiersin.org
The capacity for inhibitory control is an important cognitive process that undergoes dynamic
changes over the course of the lifespan. Robust characterization of this trajectory …

Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy

M Habibi, WH Oertel, BJ White, DC Brien, BC Coe… - Journal of …, 2022 - Springer
Objectives This study (1) describes and compares saccade and pupil abnormalities in
patients with manifest alpha-synucleinopathies (αSYN: Parkinson's disease (PD), Multiple …

Attentional modulation of eye blinking is altered by sex, age, and task structure

IC Pitigoi, BC Coe, OG Calancie, DC Brien, R Yep… - Eneuro, 2024 - eneuro.org
Spontaneous eye blinking is gaining popularity as a proxy for higher cognitive functions, as
it is readily modulated by both environmental demands and internal processes. Prior studies …

Age-related changes in pupil dynamics and task modulation across the healthy lifespan

J Huang, ML Smorenburg, R Yep, HC Riek… - Frontiers in …, 2024 - frontiersin.org
The pupil is modulated by luminance, arousal, bottom-up sensory, and top-down cognitive
signals, and has increasingly been used to assess these aspects of brain functioning in …

Impairment of Visual Fixation and Preparatory Saccade Control in Borderline Personality Disorder With and Without Comorbid Attention-Deficit/Hyperactivity Disorder

OG Calancie, AC Parr, DC Brien, BC Coe… - Biological psychiatry …, 2024 - Elsevier
Background Borderline personality disorder (BPD) is associated with heightened impulsivity,
evidenced by increased substance abuse, self-harm, and suicide attempts. Addressing …

Multimodal oculomotor assessment reveals prodromal markers of Parkinson's disease in non-manifesting LRRK2 G2019S mutation carriers

HC Riek, NP Visanji, IC Pitigoi, DG Di Luca… - npj Parkinson's …, 2024 - nature.com
Oculomotor behaviour changes in patients with Parkinson's disease (PD) are a promising
source of prodromal disease markers. Capitalizing on this phenomenon to facilitate early …

Delayed oculomotor response associates with optic neuritis in youth with demyelinating disorders

J Huang, D Brien, BC Coe, G Longoni… - Multiple Sclerosis and …, 2023 - Elsevier
Introduction Impairment in visual and cognitive functions occur in youth with demyelinating
disorders such as multiple sclerosis, neuromyelitis optica spectrum disorder, and myelin …

Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases

HC Riek, DC Brien, BC Coe, J Huang… - Brain …, 2023 - academic.oup.com
Oculomotor tasks generate a potential wealth of behavioural biomarkers for
neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry …