The nitrogen mustards are powerful cytotoxic and lymphoablative agents and have been
used for more than 60 years. They are employed in the treatment of cancers, sarcomas, and …

Osteosarcoma (OS) is a pediatric malignant bone tumor that predominantly affects
adolescent and young adults. It has high risk for relapse and over the last four decades no …

Background: We designed the study to investigate whether methotrexate, doxorubicin, and
cisplatinum (MAP) chemotherapy strategy was still the preferred option for the survival of …

The gut microbiota is closely associated with tumor progression and treatment in a variety of
cancers. However, the alteration of the gut microbiota during the progression and …

Purpose Describe clinical characteristics and outcome of Li–Fraumeni syndrome (LFS)‐
associated osteosarcomas. Methods TP53 germline pathogenic/likely pathogenic variant …

Objective: To evaluate the effects of ifosfamide combined with liposome doxorubicin on
osteosarcoma (OS) and its effects on serum IL-10, TNF-α, and IFN-γ in patients with OS …

Previous studies have reported the correlation between gut microbiota (GM), GM-derived
metabolites, and various intestinal and extra-intestinal cancers. However, limited studies …

In children and young adults, primary malignant bone tumours are mainly composed of
osteosarcoma and Ewing's sarcoma. Despite advances in treatments, nearly 40% of patients …

Predicting a response of osteosarcoma patients to chemotherapy, such as doxorubicin or
high-dose methotrexate cocktail, remains a challenge in the clinic. Moreover, the prognostic …

Aims: Diallyl trisulfide (DATS), an organosulphur compound derived from garlic, has been
shown to have good anti-cancer properties. It inhibits the expression of epidermal growth …