Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …

Amide bond forming reactions are critical for both polypeptide synthesis and medicinal
chemistry. Most current approaches for amidation employ stoichiometric activating agents …

Natural DNA is exquisitely evolved to store genetic information. The chirally inverted l-DNA,
possessing the same informational capacity but resistant to biodegradation, may serve as a …

Herpes simplex virus-1 (HSV-1) utilizes multiple viral surface glycoproteins to trigger virus
entry and fusion. Among these glycoproteins, glycoprotein D (gD) functions as a receptor …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Activity‐based E2 conjugating enzyme (E2)‐ubiquitin (Ub) probes have recently emerged as
effective tools for studying the molecular mechanism of E3 ligase (E3)‐catalyzed …

The β2-adrenergic receptor (β2AR) is a G-protein-coupled receptor (GPCR) that responds to
the hormone adrenaline and is an important drug target in the context of respiratory …

An enantioselective synthesis of unnatural pyrazole‐based α‐chiral amino acid derivatives
from the asymmetric reaction of N‐aryl‐5‐aminopyrazoles with β, γ‐alkynyl‐α‐imino esters …

A bioinspired semisynthesis of human‐interleukin‐6 bearing N‐glycan at Asn143
(143glycosyl‐IL‐6) was performed by intentional glycosylation effects and protein folding …

Circular economy and aqueous synthesis are attractive concepts for sustainable chemistry.
Here it is reported that the two can be combined in the universal method for peptide …