Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Large-scale gradients in human cortical organization
Recent advances in map** cortical areas in the human brain provide a basis for
investigating the significance of their spatial arrangement. Here we describe a dominant …
investigating the significance of their spatial arrangement. Here we describe a dominant …
Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder
The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent …
are not well understood. Using a large neuroimaging dataset, we identified three latent …
Standardizing workflows in imaging transcriptomics with the abagen toolbox
Gene expression fundamentally shapes the structural and functional architecture of the
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …
Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes
Patients with major depressive disorder (MDD) exhibit concurrent deficits in both sensory
and higher-order cognitive processing. Connectome studies have suggested a principal …
and higher-order cognitive processing. Connectome studies have suggested a principal …
A practical guide to linking brain-wide gene expression and neuroimaging data
The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …
[HTML][HTML] Generative modeling of brain maps with spatial autocorrelation
Studies of large-scale brain organization have revealed interesting relationships between
spatial gradients in brain maps across multiple modalities. Evaluating the significance of …
spatial gradients in brain maps across multiple modalities. Evaluating the significance of …
Microstructural and functional gradients are increasingly dissociated in transmodal cortices
While the role of cortical microstructure in organising neural function is well established, it
remains unclear how structural constraints can give rise to more flexible elements of …
remains unclear how structural constraints can give rise to more flexible elements of …
Functional neuroimaging as a catalyst for integrated neuroscience
Functional magnetic resonance imaging (fMRI) enables non-invasive access to the awake,
behaving human brain. By tracking whole-brain signals across a diverse range of cognitive …
behaving human brain. By tracking whole-brain signals across a diverse range of cognitive …
Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics
AM Buch, C Liston - Neuropsychopharmacology, 2021 - nature.com
Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …