Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight

JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Large-scale gradients in human cortical organization

JM Huntenburg, PL Bazin, DS Margulies - Trends in cognitive sciences, 2018 - cell.com
Recent advances in map** cortical areas in the human brain provide a basis for
investigating the significance of their spatial arrangement. Here we describe a dominant …

Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder

AM Buch, PE Vértes, J Seidlitz, SH Kim… - Nature …, 2023 - nature.com
The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent …

Standardizing workflows in imaging transcriptomics with the abagen toolbox

RD Markello, A Arnatkeviciute, JB Poline, BD Fulcher… - elife, 2021 - elifesciences.org
Gene expression fundamentally shapes the structural and functional architecture of the
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …

Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes

M **a, J Liu, A Mechelli, X Sun, Q Ma, X Wang… - Molecular …, 2022 - nature.com
Patients with major depressive disorder (MDD) exhibit concurrent deficits in both sensory
and higher-order cognitive processing. Connectome studies have suggested a principal …

A practical guide to linking brain-wide gene expression and neuroimaging data

A Arnatkevic̆iūtė, BD Fulcher, A Fornito - Neuroimage, 2019 - Elsevier
The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …

[HTML][HTML] Generative modeling of brain maps with spatial autocorrelation

JB Burt, M Helmer, M Shinn, A Anticevic, JD Murray - NeuroImage, 2020 - Elsevier
Studies of large-scale brain organization have revealed interesting relationships between
spatial gradients in brain maps across multiple modalities. Evaluating the significance of …

Microstructural and functional gradients are increasingly dissociated in transmodal cortices

C Paquola, R Vos De Wael, K Wagstyl… - PLoS …, 2019 - journals.plos.org
While the role of cortical microstructure in organising neural function is well established, it
remains unclear how structural constraints can give rise to more flexible elements of …

Functional neuroimaging as a catalyst for integrated neuroscience

ES Finn, RA Poldrack, JM Shine - Nature, 2023 - nature.com
Functional magnetic resonance imaging (fMRI) enables non-invasive access to the awake,
behaving human brain. By tracking whole-brain signals across a diverse range of cognitive …

Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics

AM Buch, C Liston - Neuropsychopharmacology, 2021 - nature.com
Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …