Primary open-angle glaucoma

RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …

Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine

X Zhan, J Li, Y Guo, O Golubnitschaja - EPMA Journal, 2021 - Springer
Over the last two decades, a large number of non-communicable/chronic disorders reached
an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular …

Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

H Chen, KS Cho, THK Vu, CH Shen, M Kaur… - Nature …, 2018 - nature.com
Glaucoma is the most prevalent neurodegenerative disease and a leading cause of
blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not …

Interleukin-17A: the key cytokine in neurodegenerative diseases

J Chen, X Liu, Y Zhong - Frontiers in aging neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases are characterized by the loss of neurons and/or myelin sheath,
which deteriorate over time and cause dysfunction. Interleukin 17A is the signature cytokine …

Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma

C He, W **u, Q Chen, K Peng, X Zhu, Z Wang… - Science Translational …, 2023 - science.org
Glaucoma is the leading cause of irreversible blindness. Currently, most therapeutic
strategies aim to reduce elevated intraocular pressure (EIOP), but this does not always halt …

Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age‐related macular degeneration, glaucoma and cataract

JC Ten Berge, Z Fazil, LI van den Born… - Acta …, 2019 - Wiley Online Library
Purpose To analyse intraocular cytokine levels and prevalence of intraocular antiretinal
antibodies (ARA s) in patients with retinitis pigmentosa (RP), age‐related macular …

Cholinergic nervous system and glaucoma: From basic science to clinical applications

MA Faiq, G Wollstein, JS Schuman, KC Chan - Progress in retinal and eye …, 2019 - Elsevier
The cholinergic system has a crucial role to play in visual function. Although cholinergic
drugs have been a focus of attention as glaucoma medications for reducing eye pressure …

Tears as a source of biomarkers for ocular and systemic diseases

NT und Hohenstein-Blaul, S Funke, FH Grus - Experimental eye research, 2013 - Elsevier
The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers
which are correlated with a certain disease. Tear proteins have been investigated …

Neuroinflammation in primary open-angle glaucoma

S Vernazza, S Tirendi, AM Bassi, CE Traverso… - Journal of clinical …, 2020 - mdpi.com
Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness
worldwide. Increasing evidence suggests oxidative damage and immune response defects …