Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models

CC Boyle, JE Bower, NI Eisenberger… - … & Biobehavioral Reviews, 2023 - Elsevier
Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

Astrocyte regulation of synaptic signaling in psychiatric disorders

A Kruyer, PW Kalivas, MD Scofield - Neuropsychopharmacology, 2023 - nature.com
Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in sha** neuronal synaptic activity and along with the pre-and …

[HTML][HTML] Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain …

H Liu, X Huang, J Xu, H Mao, Y Li, K Ren, G Ma… - Neurobiology of …, 2021 - Elsevier
Self-grooming is an innate, cephalo-caudal progression of body cleaning behaviors that are
found in normal rodents but exhibit repetitive and stereotyped patterns in several mouse …

Post-traumatic stress disorder: focus on neuroinflammation

J Li, L Tong, BC Schock, LL Ji - Molecular Neurobiology, 2023 - Springer
Post-traumatic stress disorder (PTSD), gaining increasing attention, is a multifaceted
psychiatric disorder that occurs following a stressful or traumatic event or series of events …

Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom

PW Kalivas, SL Gourley, MP Paulus - Neuroscience & Biobehavioral …, 2023 - Elsevier
Spontaneous thought is an adaptive cognitive process that can produce novel and insightful
thought sequences useful in guiding future behavior. In many psychiatric disorders …

Repeated binge‐like eating episodes in female rats alter adenosine A2A and dopamine D2 receptor genes regulation in the brain reward system

F Mercante, E Micioni Di Bonaventura… - … Journal of Eating …, 2024 - Wiley Online Library
Objective Binge‐eating disorder is an eating disorder characterized by recurrent binge‐
eating episodes, during which individuals consume excessive amounts of highly palatable …

(2R, 6R)-hydroxynorketamine improves PTSD-associated behaviors and structural plasticity via modulating BDNF-mTOR signaling in the nucleus accumbens

L Gou, Y Li, S Liu, H Sang, J Lan, J Chen… - Journal of Affective …, 2023 - Elsevier
Background Post-traumatic stress disorder (PTSD) is a mental illness caused by either
experiencing or observing a traumatic event that is perceived to pose a serious risk to one's …

Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats

S Cheng, J Xu, W Wang, R Wang, H Li, Z Jiang… - …, 2023 - Springer
Rationale and objective Post-traumatic stress disorder (PTSD) is a prevalent and debilitating
psychiatric disorder. However, its specific etiological mechanism remains unclear. Previous …

[HTML][HTML] Beyond the neuron: Role of non-neuronal cells in stress disorders

F Cathomas, LM Holt, EM Parise, J Liu, JW Murrough… - Neuron, 2022 - cell.com
Stress disorders are leading causes of disease burden in the US and worldwide, yet
available therapies are fully effective in less than half of all individuals with these disorders …

Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety‐like behaviors in mice

BF Fan, B Hao, YD Dai, L Xue, YW Shi, L Liu… - Brain …, 2022 - Wiley Online Library
Stress‐induced neuroepigenetic programming gains growing more and more interest in the
studies of the etiology of posttraumatic stress disorder (PTSD). However, seldom attention is …