Alzheimer's disease (AD) is characterized by β-amyloid plaques and intraneuronal τ
aggregation usually associated with cerebral amyloid angiopathy (CAA). Both β-amyloid …

Protein dyshomeostasis is the common mechanism of neurodegenerative diseases such as
Alzheimer's disease (AD). Aging is the key risk factor, as the capacity of the proteostasis …

Age is characterized by chronic inflammation, leading to synaptic dysfunction and dementia
because the clearance of protein waste is reduced. The clearance of proteins depends …

Extracellular deposition of amyloid β-protein (Aβ) in amyloid plaques and intracellular
accumulation of abnormally phosphorylated τ-protein (p-τ) in neurofibrillary tangles (NFTs) …

Alzheimer's disease is characterized by the deposition of amyloid-β peptide in the brain. N-
terminal truncation resulting in the formation of AβN3pE and phosphorylation at serine 8 …

Extracellular matrix (ECM) molecules that are released by neurons and glial cells form
perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose …

The oligomer hypothesis for Alzheimer's disease (AD) was introduced in 1998. It was based
on evidence that oligomers could exist free of amyloid fibrils, that fibril-free oligomer …

Abstract Background Motor neurons (MNs), which are primarily affected in amyotrophic
lateral sclerosis (ALS), are a specialized type of neurons that are long and non-dividing …

To understand neuroinflammation-related gene regulation during normal aging and in
sporadic Alzheimer disease (sAD), we performed functional genomics analysis and …

Alzheimer's disease (AD) has been associated with type II diabetes (T2D) and obesity in
several epidemiologic studies. To determine whether AD neuropathology can cause …