The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Meiotic crossovers (COs) have intriguing patterning properties, including CO interference,
the tendency of COs to be well-spaced along chromosomes, and heterochiasmy, the marked …

DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …

Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …

Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …

Abstract The multifunctional Survival Motor Neuron (SMN) protein is required for the survival
of all organisms of the animal kingdom. SMN impacts various aspects of RNA metabolism …

Heritability and genome stability are shaped by meiotic recombination, which is initiated via
hundreds of DNA double-strand breaks (DSBs). The distribution of DSBs throughout the …

Meiotic recombination commences with hundreds of programmed DNA breaks; however, the
degree to which they are accurately repaired remains poorly understood. We report that …