Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …

Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …

Tumor suppressor p53 plays an important role in cancer prevention. Under normal
conditions, p53 is maintained at a low level. However, in response to various cellular …

The DNA-dependent protein kinase (DNA–PK) is a nuclear serine/threonine protein kinase
that is activated upon association with DNA. Biochemical and genetic data have revealed …

Over the past decade, our understanding of apoptosis, or programmed cell death, has
increased greatly, with the identification of some of the major components of the apoptotic …

Full activation of protein kinase B (PKB)/Akt requires phosphorylation on Thr-308 and Ser-
473 by 3-phosphoinositide-dependent kinase-1 (PDK1) and Ser-473 kinase (S473K) …

Double-strand breaks (DSBs) arise endogenously during normal cellular processes and
exogenously by genotoxic agents such as ionizing radiation (IR). DSBs are one of the most …

Cell death has been questioned as a mechanism of ventricular failure. In this report, we
tested the hypothesis that apoptotic death of myocytes, endothelial cells, and fibroblasts is …

PKCδ (protein kinase Cδ) is a serine/threonine kinase that plays a key role in growth
regulation and tissue remodelling. Traditional models of PKC activation have focused on …

The isoforms of the PKC family are activated in response to mitogenic stimuli, to
inflammatory stimuli, and to stress and play important roles in a variety of cellular functions …