• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Importance Sex differences in dementia risk are unclear, but some studies have found
greater risk for women. Objective To determine associations between sex and cognitive …

Hypertrophic cardiomyopathy (HCM) is a common, serious, genetic heart disorder. Rare
pathogenic variants in sarcomere genes cause HCM, but with unexplained phenotypic …

Background The most appropriate targets for systolic blood pressure to reduce
cardiovascular morbidity and mortality among persons without diabetes remain uncertain …

Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers,
and health systems. Structural and functional alterations of vessels accumulate throughout …

Ubiquitous blood pressure (BP) monitoring is needed to improve hypertension detection and
control and is becoming feasible due to recent technological advances such as in wearable …

Hypertension is the most important modifiable cause of cardiovascular (CV) disease and all-
cause mortality worldwide. Despite the positive correlations between blood pressure (BP) …

Mitchell Arterial Stiffness and Hypertension 211 in PP that is associated with high incidence
of predominantly systolic hypertension in older people. One of the foregoing studies of …