Engineered nucleases enable the targeted alteration of nearly any gene in a wide range of
cell types and organisms. The newly-developed transcription activator-like effector …

Current technology enables the production of highly specific genome modifications with
excellent efficiency and specificity. Key to this capability are targetable DNA cleavage …

Precise studies of plant, animal and human genomes enable remarkable opportunities of
obtained data application in biotechnology and medicine. However, knowing nucleotide …

Abstract Customized TALENs and Cas9/gRNAs have been used for targeted mutagenesis in
zebrafish to induce indels into protein-coding genes. However, indels are usually not …

Insect genome engineering is crucial for gene functional analysis and the long-term
development of novel pest control technologies. The recently developed engineered …

Transcription activator‐like effector (TALE) nucleases (TALENs) have recently emerged as a
revolutionary genome editing tool in many different organisms and cell types. The site …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49881125&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

The transcription activator–like effectors (TALEs) and the RNA-guided clustered regularly
interspaced short palindromic repeat (CRISPR) associated protein (Cas9) utlilize distinct …

The generation of genome-modified animals is a powerful approach to analyze gene
functions. The CAS9/guide RNA (gRNA) system is expected to become widely used for the …

Discovered as a bacterial adaptive immune system, CRISPR/Cas9 (clustered, regularly
interspaced, short palindromic repeat/CRISPR associated) is being developed as an …