Ovarian damage from chemotherapy and current approaches to its protection
N Spears, F Lopes, A Stefansdottir… - Human reproduction …, 2019 - academic.oup.com
Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life
BACKGROUND Regulated cell death is a fundamental component of numerous
physiological processes; spanning from organogenesis in utero, to normal cell turnover …
physiological processes; spanning from organogenesis in utero, to normal cell turnover …
Crosstalk between PTEN/PI3K/Akt signalling and DNA damage in the oocyte: implications for primordial follicle activation, oocyte quality and ageing
The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …
The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing
BACKGROUND Within the ovary, oocytes are stored in long-lived structures called
primordial follicles, each comprising a meiotically arrested oocyte, surrounded by somatic …
primordial follicles, each comprising a meiotically arrested oocyte, surrounded by somatic …
Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63
The survival rate of cancer patients is steadily increasing, owing to more efficient therapies.
Understanding the molecular mechanisms of chemotherapy-induced premature ovarian …
Understanding the molecular mechanisms of chemotherapy-induced premature ovarian …
Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide
Cancer therapy can cause off-target effects including ovarian damage, which may result in
primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles …
primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles …
Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility
QN Nguyen, N Zerafa, SH Liew, FH Morgan… - Cell death & …, 2018 - nature.com
Female gametes are stored in the ovary in structures called primordial follicles, the supply of
which is non-renewable. It is well established that DNA-damaging cancer treatments can …
which is non-renewable. It is well established that DNA-damaging cancer treatments can …
The DNA damage checkpoint eliminates mouse oocytes with chromosome synapsis failure
Pairing and synapsis of homologous chromosomes during meiosis is crucial for producing
genetically normal gametes and is dependent upon repair of SPO11-induced double-strand …
genetically normal gametes and is dependent upon repair of SPO11-induced double-strand …
TAp63 determines the fate of oocytes against DNA damage
Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target
effect. However, their oocyte death pathway has been debated. Here, we clarified the …
effect. However, their oocyte death pathway has been debated. Here, we clarified the …
Bone marrow-derived mesenchymal stem cells reverse radiotherapy-induced premature ovarian failure: emphasis on signal integration of TGF-β, Wnt/β-catenin and …
Radiotherapy is an indispensable cancer treatment approach. However, it is associated with
hazardous consequences on multiple organs characterized by insidious worsening severity …
hazardous consequences on multiple organs characterized by insidious worsening severity …