Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor
vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical …

Osteoarthritis is a leading cause of pain and disability across the world. With an aging
population its prevalence is likely to further increase. Current accepted medical treatment …

Biomimetic drug delivery system offers new opportunities to mimic the biological
particulates, including cells, vesicles and viruses for enhancing biocompatibility and …

Antiplatelet treatment is of fundamental importance in combatting functions/dysfunction of
platelets in the pathogenesis of cardiovascular and inflammatory diseases. Dysfunction of …

Platelet concentrates such as platelet-rich plasma (PRP) have gained popularity in sports
medicine and orthopaedics to promote accelerated physiologic healing and return to …

Osteoarthritis (OA) is a common disease involving joint damage, an inadequate healing
response and progressive deterioration of the joint architecture. Autologous blood-derived …

Background Full-thickness chondral defects and early osteoarthritis continue to present
major challenges for the patient and the orthopaedic surgeon as a result of the limited …

Human platelets arise as subcellular fragments of megakaryocytes in bone marrow. The
physiologic demand, presence of disease such as cancer, or drug effects can regulate the …

Cartilage defects (CDs) and the most common joint disease, osteoarthritis (OA), are
characterized by degeneration of the articular cartilage that ultimately leads to joint …

Platelet‐derived Growth Factors (GFs) are biologically active peptides that enhance tissue
repair mechanisms such as angiogenesis, extracellular matrix remodeling, and cellular …