There has been an upsurge in the number of clinical trials involving chemically modified
oligonucleotide-based drug candidates after the FDA approval of Vitravene, Macugen, and …

Long considered the forgotten elements of the periodic table and sometimes thought of
merely as atomic number place holders, the lanthanides, in the last decades, are easily …

Reduction provides an important method for functional group interconversion in organic
synthesis. The development of cleaner and safe synthetic methods and technologies for …

An efficient method for the synthesis of 4 'α-branched 2 '-deoxyadenosines starting from 2 '-
deoxyadenosine has been developed utilizing a novel radical cyclization reaction with a …

Electrophilic addition of NBS/pivalic acid (bromopivaloyloxylation) to l-[3, 5-bis-0-(feri-butyldi-
methylsilyl)-2-deoxy-D-ezyi/iro-pent-l-enofuranosyl] uracil (2), readily accessible from 0* 12 …

A versatile synthetic route to 3-deaza-3-haloinosines 6− 8 and 46,-adenosines 15− 17 and
64, and-guanosines 25, 26, and 52 is described. 3-Deaza-3-chloro-,-bromo-, and …

Nucleoside anomeric radicals were formed through 1, 5-translocation of vinyl radicals
generated from the 2, 2-dibromovinyl group tethered at the uracil 6-position (1, 2, and 4) by …

Abstract A 1, 5‐radical translocation from a conveniently situated alkoxyl or vinyl radical next
to the C‐1′ position is the key step for the successful radical‐based cascade reactions that …

Abstraction of a hydrogen atom from the C-1′ position of specific cytidine residues of the
sugar backbone of DNA corresponds to a minor event in the mechanism of action of …

Epoxidation of 3 ', 5 '-O-(di-tert-butylsilylene)-1 ', 2 '-unsaturated uridine (11) with
dimethyldioxirane proceeded from the α-face to give the 1 ', 2 '-α-epoxide 12. Upon reacting …