Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II

TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - researchgate.net
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

[HTML][HTML] Syzygium cumini (L.) Skeels essential oil and its major constituent α-pinene exhibit anti-Leishmania activity through immunomodulation in vitro

KA da Franca Rodrigues, LV Amorim, CN Dias… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Syzygium cumini (L.) Skeels (Myrtaceae), commonly
known as “jambolão” in Brazil is widely used in folk medicine against leishmaniasis …

Plant derived therapeutics for the treatment of Leishmaniasis

R Sen, M Chatterjee - Phytomedicine, 2011 - Elsevier
Diseases caused by insect borne trypanosomatid parasites are significant, yet remain a
neglected public health problem. Leishmania, a unicellular protozoan parasite is the …

Fruitful decade for antileishmanial compounds from 2002 to late 2011

H Hussain, A Al-Harrasi, A Al-Rawahi, IR Green… - Chemical …, 2014 - ACS Publications
Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …

A review of the antimalarial, antitrypanosomal, and antileishmanial activities of natural compounds isolated from Nigerian flora

MA Ungogo, GU Ebiloma, N Ichoron, JO Igoli… - Frontiers in …, 2020 - frontiersin.org
The West African country Nigeria features highly diverse vegetation and climatic conditions
that range from rain forest bordering the Atlantic Ocean in the South to the Desert (Sahara) …

A review on new natural and synthetic anti-leishmanial chemotherapeutic agents and current perspective of treatment approaches.

N Majumder, A Banerjee, S Saha - Acta Tropica, 2023 - Elsevier
Leishmaniases are considered among the most neglected yet dangerous parasitic diseases
worldwide. According to the recent WHO report (Weekly Epidemiological Record, Sep …

Constructing Quaternary Stereogenic Centers Using Tertiary Organocuprates and Tertiary Radicals. Total Synthesis of trans-Clerodane Natural Products

DS Müller, NL Untiedt, AP Dieskau… - Journal of the …, 2015 - ACS Publications
A new concise construction of trans-clerodane diterpenoids is reported in which oxacyclic
and trans-hydronaphthalene fragments are coupled, and the critical C9-quaternary carbon …

Induction of mitochondrial dysfunction and oxidative stress in Leishmania donovani by orally active clerodane diterpene

M Kathuria, A Bhattacharjee… - Antimicrobial agents …, 2014 - Am Soc Microbiol
This study was performed to investigate the mechanistic aspects of cell death induced by a
clerodane diterpene (K-09) in Leishmania donovani promastigotes that was previously …

Plants as antileishmanial agents: current scenario

N Ullah, A Nadhman, S Siddiq, S Mehwish… - Phytotherapy …, 2016 - Wiley Online Library
Leishmaniasis is a clinical manifestation caused by the parasites of the genus Leishmania.
Plants are reservoirs of bioactive compounds, which are known to be chemically balanced …