The increase in cancer cases is undoubtedly affecting the development of new therapeutic
approaches. Polymeric nanoparticles are of great interest. Due to their relatively small size …

The poor access of therapeutic drugs and genetic material into the central nervous system
due to the presence of the blood–brain barrier often limits the development of effective …

Based on the facilitative glucose transporter (GLUT) over-expression on both blood–brain
barrier (BBB) and glioma cells, 2-deoxy-d-glucose modified poly (ethylene glycol)-co-poly …

The aim of our study was to develop hyaluronic acid-coated, paclitaxel-loaded,
nanostructured lipid carriers (HA-NLCs) prepared via electrostatic attraction for delivering …

The development of a drug delivery strategy which can mediate efficient tumor targeting
together with high cellular internalization and extensive vascular extravasation is essential …

As therapies continue to increase the lifespan of patients with breast cancer, the incidence of
brain metastases has steadily increased, affecting a significant number of patients with …

Pediatric high-grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPG), are
the leading cause of cancer-related death in children. While it is clear that surgery (if …

The treatment for ischemic stroke is one of the most challenging problems and the
therapeutic effect remains unsatisfied due to the poor permeation of drugs across the blood …

Limited penetration of antineoplastic agents is one of the contributing factors for
chemotherapy failure of many solid tumors. In order to enhance drug penetration into solid …

Targeted DNA nanoparticles have been identified as one of the most promising nanocarriers
in anti-glioma drug delivery. We established a multifunctional nanosystem for targeted …