[HTML][HTML] Assembly, Activation, and Helicase Actions of MCM2-7: Transition from Inactive MCM2-7 Double Hexamers to Active Replication Forks
Z You, H Masai - Biology, 2024 - mdpi.com
Simple Summary MCM2-7, evolutionarily conserved and essential for DNA replication,
functions as the central factor for the eukaryotic replicative DNA helicase. Here, we …
functions as the central factor for the eukaryotic replicative DNA helicase. Here, we …
Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa
Metazoan genomes are copied bidirectionally from thousands of replication origins.
Replication initiation entails the assembly and activation of two CMG helicases (Cdc45⋅ …
Replication initiation entails the assembly and activation of two CMG helicases (Cdc45⋅ …
Dual DNA replication modes: varying fork speeds and initiation rates within the spatial replication program in Xenopus
Large vertebrate genomes duplicate by activating tens of thousands of DNA replication
origins, irregularly spaced along the genome. The spatial and temporal regulation of the …
origins, irregularly spaced along the genome. The spatial and temporal regulation of the …
The balance between ATR and DDK activities controls TopBP1-mediated locking of dormant origins at the pre-IC stage
S Koundrioukoff, SJ Kim, N Alary, A Toffano… - bioRxiv, 2023 - biorxiv.org
Replication stress, a major hallmark of cancers, and ensuing genome instability source from
impaired progression of replication forks. The first line of defense against fork slowing is …
impaired progression of replication forks. The first line of defense against fork slowing is …
ATR and TopBP1 oppose to control dormant origin building, providing a first defence against replication stress
M Debatisse, S Koundrioukoff, S Kim, N Alary… - 2024 - researchsquare.com
Replication stress, a major hallmark of cancers, sources from replication fork slowing or
blocking. In response, activation of extra-origins, otherwise dormant, supports the replication …
blocking. In response, activation of extra-origins, otherwise dormant, supports the replication …
[PDF][PDF] Machine Learning Discoveries of GINS1-X Synergy in ETC-1922159 Treated Colorectal Cancer Cells
S Sinha - 2025 - preprints.org
GINS1 (PSF1 homolog) forms a part of complex called GINS, named after numbers 5-1-2-3
(go-ichi-ni-san in Japanese) apropos the 4 protein subunits of the complex, namely, SLD5 …
(go-ichi-ni-san in Japanese) apropos the 4 protein subunits of the complex, namely, SLD5 …
DONSON: A novel metazoan DNA replication initiation factor
Y Lim - 2024 - dash.harvard.edu
Faithful and timely duplication of the genome is required for genetic information to be
inherited during cell division, and deregulation of genome duplication causes cancer and …
inherited during cell division, and deregulation of genome duplication causes cancer and …