Recent advancements of fluorescent biosensors using semisynthetic probes
Fluorescent biosensors are crucial experimental tools for live-cell imaging and the
quantification of different biological analytes. Fluorescent protein (FP)-based biosensors are …
quantification of different biological analytes. Fluorescent protein (FP)-based biosensors are …
Tools for the recognition of sorting signals and the prediction of subcellular localization of proteins from their amino acid sequences
At the time of translation, nascent proteins are thought to be sorted into their final subcellular
localization sites, based on the part of their amino acid sequences (ie, sorting or targeting …
localization sites, based on the part of their amino acid sequences (ie, sorting or targeting …
MYC as a therapeutic target for the treatment of triple-negative breast cancer: preclinical investigations with the novel MYC inhibitor, MYCi975
M Tang, S O'Grady, J Crown, MJ Duffy - Breast Cancer Research and …, 2022 - Springer
Background MYC is one of the most frequently altered driver genes in triple-negative breast
cancer (TNBC). The aim of this study was to evaluate targeting MYC for the treatment of …
cancer (TNBC). The aim of this study was to evaluate targeting MYC for the treatment of …
Spatial stable isotopic labeling by amino acids in cell culture: Pulse-chase labeling of three-dimensional multicellular spheroids for global proteome analysis
Three-dimensional cell cultures, or spheroids, are important model systems for cancer
research because they recapitulate chemical and phenotypic aspects of in vivo tumors …
research because they recapitulate chemical and phenotypic aspects of in vivo tumors …
[HTML][HTML] IKBIP, a novel glioblastoma biomarker, maintains abnormal proliferation of tumor cells by inhibiting the ubiquitination and degradation of CDK4
K Li, G Huang, Z Wang, R Yang, W Zhang, B Ni… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Sustained proliferative signaling is a crucial hallmark and therapeutic target in glioblastoma
(GBM); however, new intrinsic regulators and their underlying mechanisms remain to be …
(GBM); however, new intrinsic regulators and their underlying mechanisms remain to be …
An “OFF–ON–OFF” fluorescence protein-labeling probe for real-time visualization of the degradation of short-lived proteins in cellular systems
The ability to monitor proteolytic pathways that remove unwanted and damaged proteins
from cells is essential for understanding the multiple processes used to maintain cellular …
from cells is essential for understanding the multiple processes used to maintain cellular …
NEDD4–Mediated GSNOR Degradation Aggravates Cardiac Hypertrophy and Dysfunction
X Tang, X Liu, X Sha, Y Zhang, Y Zu, Q Fan… - Circulation …, 2025 - ahajournals.org
BACKGROUND: The decrease in S-nitrosoglutathione reductase (GSNOR) leads to an
elevation of S-nitrosylation, thereby exacerbating the progression of cardiomyopathy in …
elevation of S-nitrosylation, thereby exacerbating the progression of cardiomyopathy in …
DNAJB8 facilitates autophagic‐lysosomal degradation of viral Vif protein and restricts HIV‐1 virion infectivity by rescuing APOBEC3G expression in host cells
HSP40/DNAJ family of proteins is the most diverse chaperone family, comprising about 49
isoforms in humans. Several reports have demonstrated the functional role of a few of these …
isoforms in humans. Several reports have demonstrated the functional role of a few of these …
SPAAC pulse-chase: A novel click chemistry-based method to determine the half-life of cellular proteins
Assessing the stability and degradation of proteins is central to the study of cellular
biological processes. Here, we describe a novel pulse-chase method to determine the half …
biological processes. Here, we describe a novel pulse-chase method to determine the half …
Regulation of Neurodegeneration-associated Protein Fragments by the N-degron Pathways
Among the most salient features that underpin the development of aging-related
neurodegenerative disorders are the accumulation of protein aggregates and the decrease …
neurodegenerative disorders are the accumulation of protein aggregates and the decrease …