Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases
DR Lucey, M Clerici, GM Shearer - Clinical microbiology reviews, 1996 - Am Soc Microbiol
In the mid-1980s, Mosmann, Coffman, and their colleagues discovered that murine CD4+
helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation …
helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation …
NO inhibitions: antimicrobial properties of nitric oxide
MA De Groote, FC Fang - Clinical Infectious Diseases, 1995 - academic.oup.com
The past decade has witnessed a veritableexplosionof interest in the simplemolecule nitric
oxide (NO) as a vasodilator, neurotransmitter, and antimicrobial agent. NO and other …
oxide (NO) as a vasodilator, neurotransmitter, and antimicrobial agent. NO and other …
Altered immune responses in mice lacking inducible nitric oxide synthase
NITRIC oxide (NO) is important in many biological functions1–5. It is generated from L-
arginine by the enzyme NO synthase (NOS). The cytokine-inducible NOS (iNOS) is activated …
arginine by the enzyme NO synthase (NOS). The cytokine-inducible NOS (iNOS) is activated …
Herpes simplex virus turns off the TAP to evade host immunity
A Hill, P Jugovic, lan York, G Russ, J Bennink… - Nature, 1995 - nature.com
MANY viruses have evolved mechanisms to avoid detection by the host immune system.
Herpes simplex virus (HSV) expresses an immediate early protein, ICP47, which blocks …
Herpes simplex virus (HSV) expresses an immediate early protein, ICP47, which blocks …
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
R Kamijo, H Harada, T Matsuyama, M Bosland… - Science, 1994 - science.org
Production of nitric oxide (NO) by macrophages is important for the killing of intracellular
infectious agents. Interferon (IFN)-γ and lipopolysaccharide stimulate NO production by …
infectious agents. Interferon (IFN)-γ and lipopolysaccharide stimulate NO production by …
Covid-19 accelerates endothelial dysfunction and nitric oxide deficiency
SJ Green - Microbes and infection, 2020 - ncbi.nlm.nih.gov
Martel and colleagues provide a thoughtful review on strategies to increase airway nitric
oxide to treat and possibly prevent Covid-19 [1]. However, it is becoming apparent that the …
oxide to treat and possibly prevent Covid-19 [1]. However, it is becoming apparent that the …
The immune response to Leishmania: mechanisms of parasite control and evasion
After transmission of Leishmania parasites by sandflies, disease manifestation of the
infection requires mechanisms which allow the parasites to replicate in the mammalian host …
infection requires mechanisms which allow the parasites to replicate in the mammalian host …
Nitric oxide: cytokine-regulation of nitric oxide in host resistance to intracellular pathogens
To discover how nitric oxide (NO) synthesis is controlled in different tissues as cells within
these tissues combat intracellular pathogens, we examined three distinctively different …
these tissues combat intracellular pathogens, we examined three distinctively different …
Physiological and pathophysiological roles of nitric oxide in the central nervous system
C Szabó - Brain research bulletin, 1996 - Elsevier
Nitric oxide (NO) is produced by three distinct isoforms of nitric oxide synthases in the central
nervous system. Here, the roles of nitric oxide in the central nervous system are reviewed …
nervous system. Here, the roles of nitric oxide in the central nervous system are reviewed …
Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major.
S Stenger, H Thüring, M Röllinghoff… - The Journal of …, 1994 - rupress.org
Previous studies with inhibitors of inducible nitric oxide synthase (iNOS) suggested that high-
output production of nitric oxide (NO) is an important antimicrobial effector pathway in vitro …
output production of nitric oxide (NO) is an important antimicrobial effector pathway in vitro …