The stochastic dynamics of filopodial growth
A filopodium is a cytoplasmic projection, exquisitely built and regulated, which extends from
the leading edge of the migrating cell, exploring the cell's neighborhood. Commonly …
the leading edge of the migrating cell, exploring the cell's neighborhood. Commonly …
Spectral solutions to stochastic models of gene expression with bursts and regulation
Signal-processing molecules inside cells are often present at low copy number, which
necessitates probabilistic models to account for intrinsic noise. Probability distributions have …
necessitates probabilistic models to account for intrinsic noise. Probability distributions have …
Overcoming the bottleneck of the enzymatic cycle by steric frustration
The enormous catalytic power of natural enzymes relies on the ability to overcome the
bottleneck event in the enzymatic cycle, yet the underlying physical mechanisms are not fully …
bottleneck event in the enzymatic cycle, yet the underlying physical mechanisms are not fully …
Particle competition for complex network community detection
In many real situations, randomness is considered to be uncertainty or even confusion which
impedes human beings from making a correct decision. Here we study the combined role of …
impedes human beings from making a correct decision. Here we study the combined role of …
Molecular noise of cap** protein binding induces macroscopic instability in filopodial dynamics
Cap** proteins are among the most important regulatory proteins involved in controlling
complicated stochastic dynamics of filopodia, which are dynamic finger-like protrusions used …
complicated stochastic dynamics of filopodia, which are dynamic finger-like protrusions used …
A stochastic spectral analysis of transcriptional regulatory cascades
The past decade has seen great advances in our understanding of the role of noise in gene
regulation and the physical limits to signaling in biological networks. Here, we introduce the …
regulation and the physical limits to signaling in biological networks. Here, we introduce the …
CSI-independent non-linear signal detection in molecular communications
Molecular communications rely on diffusive propagation to transport information, which is
attractive for a variety of nano-scale applications. Due to the long-tail channel response …
attractive for a variety of nano-scale applications. Due to the long-tail channel response …
Mechano-chemical feedbacks regulate actin mesh growth in lamellipodial protrusions
During cell motion on a substratum, eukaryotic cells project sheetlike lamellipodia which
contain a dynamically remodeling three-dimensional actin mesh. A number of regulatory …
contain a dynamically remodeling three-dimensional actin mesh. A number of regulatory …
Design of active transport must be highly intricate: a possible role of myosin and Ena/VASP for G-actin transport in filopodia
Recent modeling of filopodia—the actin-based cell organelles employed for sensing and
motility—reveals that one of the key limiting factors of filopodial length is diffusional transport …
motility—reveals that one of the key limiting factors of filopodial length is diffusional transport …
Accurate Langevin approaches to simulate Markovian channel dynamics
The stochasticity of ion-channels dynamic is significant for physiological processes on
neuronal cell membranes. Microscopic simulations of the ion-channel gating with Markov …
neuronal cell membranes. Microscopic simulations of the ion-channel gating with Markov …