Effective vaccine formulations consist of several components: an antigen carrier, the antigen,
a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a …

Inappropriate and uncontrolled use of antibiotics results in the emergence of antibiotic
resistance, thereby threatening the present clinical regimens to treat infectious diseases …

As mechanisms underpinning the molecular interactions between membrane-targeting
antimicrobials and Gram-negative bacterial membranes at atomistic scale remain elusive …

Tuberculosis faces major challenges for its cure due to (a) long treatment period,(b)
emergence of drug resistance bacteria, and (c) poor patient compliance. Disrupting the …

Weakly basic drugs display poor solubility and tend to precipitate in the stomach's acidic
environment causing reduced oral bioavailability. Tracing of these orally delivered …

Ion-pair amphiphiles (IPAs) are neoteric pseudo-double-tailed compounds with potential as
a novel substitute of phospholipid. IPA, synthesized by stoichiometric/equimolar mixing of …

Gene therapy, a promising strategy for the delivery of therapeutic nucleic acids, is greatly
dependent on the development of efficient vectors. In this study, we designed and …

Push–pull type fluorophores are often exploited as a biological probe because of their high
environment-sensitivity nature. Herein, we report the potentiality of a push–pull fluorophore …

Modulation of existing drugs is required to achieve enhanced activity for cancer therapy by
lowering their effective dose. Strategies for introduction of cationic charge and …

This work focuses on the membrane perturbation, solubilisation and thermotropic phase
transition process of 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) MLVs induced …