Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

[HTML][HTML] Relieving metabolic burden to improve robustness and bioproduction by industrial microorganisms

J Mao, H Zhang, Y Chen, L Wei, J Liu, J Nielsen… - Biotechnology …, 2024 - Elsevier
Metabolic burden is defined by the influence of genetic manipulation and environmental
perturbations on the distribution of cellular resources. The rewiring of microbial metabolism …

Engineering robust production microbes for large-scale cultivation

M Wehrs, D Tanjore, T Eng, J Lievense, TR Pray… - Trends in …, 2019 - cell.com
Systems biology and synthetic biology are increasingly used to examine and modulate
complex biological systems. As such, many issues arising during scaling-up microbial …

[HTML][HTML] Dynamic control in metabolic engineering: Theories, tools, and applications

CJ Hartline, AC Schmitz, Y Han, F Zhang - Metabolic engineering, 2021 - Elsevier
Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

Synthetic biochemistry: the bio-inspired cell-free approach to commodity chemical production

JU Bowie, S Sherkhanov, TP Korman, MA Valliere… - Trends in …, 2020 - cell.com
Metabolic engineering efforts that harness living organisms to produce natural products and
other useful chemicals face inherent difficulties because the maintenance of life processes …

Challenges and opportunities in biological funneling of heterogeneous and toxic substrates beyond lignin

AJ Borchert, WR Henson, GT Beckham - Current opinion in biotechnology, 2022 - Elsevier
Significant developments in the understanding and manipulation of microbial metabolism
have enabled the use of engineered biological systems toward a more sustainable energy …

Synthetic biological approaches for Optogenetics and tools for transcriptional Light‐control in bacteria

A Baumschlager, M Khammash - Advanced biology, 2021 - Wiley Online Library
Light has become established as a tool not only to visualize and investigate but also to steer
biological systems. This review starts by discussing the unique features that make light such …

Changing form and function through carotenoids and synthetic biology

ET Wurtzel - Plant physiology, 2019 - academic.oup.com
Changing Form and Function through Carotenoids and Synthetic Biology | Plant Physiology |
Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals Books …

Redesigning regulatory components of quorum-sensing system for diverse metabolic control

C Ge, Z Yu, H Sheng, X Shen, X Sun, Y Zhang… - Nature …, 2022 - nature.com
Quorum sensing (QS) is a ubiquitous cell–cell communication mechanism that can be
employed to autonomously and dynamically control metabolic fluxes. However, since the …

Host-aware synthetic biology

A Boo, T Ellis, GB Stan - Current Opinion in Systems Biology, 2019 - Elsevier
Unnatural gene expression imposes a load on engineered microorganisms which
decreases their growth and subsequent production yields, a phenomenon known as burden …