Inversions are structural mutations that reverse the sequence of a chromosome segment
and reduce the effective rate of recombination in the heterozygous state. They play a major …

Stochastic simulation is a key tool in population genetics, since the models involved are
often analytically intractable and simulation is usually the only way of obtaining ground-truth …

A central challenge in the analysis of genetic variation is to provide realistic genome
simulation across millions of samples. Present day coalescent simulations do not scale well …

Progress on understanding how genome structure evolves is accelerating with the arrival of
new genomic, comparative, and theoretical approaches. This article reviews progress in …

Chromosomal inversions, structural mutations that reverse a segment of a chromosome,
cause suppression of recombination in the heterozygous state. Several studies have shown …

The association of chromosome rearrangements (CRs) with speciation is well established,
and there is a long history of theory and evidence relating to “chromosomal speciation.” …

How polymorphisms are maintained within populations over long periods of time remains
debated, because genetic drift and various forms of selection are expected to reduce …

The evolution of complex traits in heterogeneous environments may shape the order of
genes within chromosomes. Drosophila pseudoobscura has a rich gene arrangement …

Long-range linkage disequilibria (LRLD) between sites that are widely separated on
chromosomes may suggest that population admixture, epistatic selection, or other …

Chromosomal inversion polymorphisms are common in animals and plants, and recent
models suggest that alternative arrangements spread by capturing different combinations of …