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Alternative splicing as a target for cancer treatment
Alternative splicing is a key mechanism determinant for gene expression in metazoan.
During alternative splicing, non-coding sequences are removed to generate different mature …
During alternative splicing, non-coding sequences are removed to generate different mature …
Biotechnology approaches for natural product discovery, engineering, and production based on Burkholderia bacteria
Highlights•Approaches used include RecET recombination, CRISPR–Cas9, and transposon
mutagenesis.•RecET-like recombinases and CRISPR–Cas systems were identified in …
mutagenesis.•RecET-like recombinases and CRISPR–Cas systems were identified in …
Total syntheses of thailanstatins A–C, spliceostatin D, and analogues thereof. Stereodivergent synthesis of tetrasubstituted dihydro-and tetrahydropyrans and design …
KC Nicolaou, D Rhoades… - Journal of the American …, 2018 - ACS Publications
Efficient and selective total syntheses of spliceosome modulating natural products
thailanstatins A–C and spliceostatin D are reported. A number of stereoselective methods for …
thailanstatins A–C and spliceostatin D are reported. A number of stereoselective methods for …
Genome In Silico and In Vitro Analysis of the Probiotic Properties of a Bacterial Endophyte, Bacillus Paranthracis Strain MHSD3
Spore-forming Bacillus species are gaining interest in human health recently, due to their
ability to withstand the harsh environment of the gastrointestinal tract. The present study …
ability to withstand the harsh environment of the gastrointestinal tract. The present study …
Unusual and Highly Bioactive Sesterterpenes Synthesized by Pleurotus ostreatus during Coculture with Trametes robiniophila Murr
XT Shen, XH Mo, LP Zhu, LL Tan, FY Du… - Applied and …, 2019 - journals.asm.org
Candida albicans and Cryptococcus neoformans, human-pathogenic fungi found worldwide,
are receiving increasing attention due to high morbidity and mortality in …
are receiving increasing attention due to high morbidity and mortality in …
Comparative genomics provides insights into the potential biocontrol mechanism of two Lysobacter enzymogenes strains with distinct antagonistic activities
S Xu, Z Zhang, X ** new targeting strategy for androgen receptor variants in castration resistant prostate cancer
The presence of androgen receptor variant 7 (AR‐V7) variants becomes a significant
hallmark of castration‐resistant prostate cancer (CRPC) relapsed from hormonal therapy …
hallmark of castration‐resistant prostate cancer (CRPC) relapsed from hormonal therapy …
Design, synthesis, and biological investigation of thailanstatin A and spliceostatin D analogues containing tetrahydropyran, tetrahydrooxazine, and fluorinated …
Thailanstatin A and spliceostatin D, two naturally occurring molecules endowed with potent
antitumor activities by virtue of their ability to bind and inhibit the function of the spliceosome …
antitumor activities by virtue of their ability to bind and inhibit the function of the spliceosome …
[HTML][HTML] Do global regulators hold the key to production of bacterial secondary metabolites?
SS Thapa, A Grove - Antibiotics, 2019 - mdpi.com
The emergence of multiple antibiotic resistant bacteria has pushed the available pool of
antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource …
antibiotics to the brink. Bacterial secondary metabolites have long been a valuable resource …
Understanding Autologous Spliceostatin Transcriptional Regulation to Derive Parts for Heterologous Expression in a Burkholderia Bacterial Host
BI Adaikpoh, SB Romanowski… - ACS synthetic …, 2023 - ACS Publications
Burkholderia β-Proteobacteria are emerging sources of natural products. We are interested
in develo** Burkholderia sp. FERM BP-3421 into a synthetic biology chassis to facilitate …
in develo** Burkholderia sp. FERM BP-3421 into a synthetic biology chassis to facilitate …