Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the
natural pacemaker of the heart, making it responsible for initiating each-and-every normal …

Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …

Background: The ability to increase heart rate during exercise and other stressors is a key
homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate …

Electronic pacemakers can treat electrical conduction disorders in hearts; however, they are
invasive, bulky, and linked to increased incidence of infection at the tissue–device interface …

Objectives This study sought to identify subcellular Ca2+ signals within and among cells
comprising the sinoatrial node (SAN) tissue. Background The current paradigm of SAN …

Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …

Loss or dysregulation of the normally precise control of heart rate via the autonomic nervous
system plays a critical role during the development and progression of cardiovascular …

The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac
automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node …

Background: Up to 50% of the adult human sinoatrial node (SAN) is composed of dense
connective tissue. Cardiac diseases including heart failure (HF) may increase fibrosis within …