Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …

Technology at the single‐cell level has advanced dramatically in characterizing molecular
heterogeneity. These technologies have enabled cell subtype diversity to be seen in all …

Integrating human genomics and proteomics can help elucidate disease mechanisms,
identify clinical biomarkers and discover drug targets,,–. Because previous proteogenomic …

With the changing disease spectrum, atherosclerosis has become increasingly prevalent
worldwide and the associated diseases have emerged as the leading cause of death. Due …

Innate immune pathways play a crucial role in the development of atherosclerosis, from
sensing initial danger signals to the long-term reprogramming of immune cells. Despite the …

BACKGROUND: Perivascular adipose tissue (PVAT) is vital for vascular homeostasis, and
PVAT dysfunction is associated with increased atherosclerotic plaque burden. But the …

Background: Tanshinone IIA (TIIA) is the major lipid-soluble active ingredient of the
traditional Chinese medicine Salvia miltiorrhiza, which slows down atherosclerosis (AS) …

Quantitative abnormalities in factor VIII (FVIII) and its binding partner, von Willebrand factor
(VWF), are associated with an increased risk of bleeding or thrombosis, and pathways that …

Liver sinusoidal endothelial cells (LSECs) control clearance of Transforming growth factor,
beta-induced, 68kDa (TGFBi) and Periostin (POSTN) through scavenger receptors Stabilin-1 …

Background Periostin is an extracellular matrix protein that plays a critical role in cell fate
determination and tissue remodeling, but the underlying role and mechanism of periostin in …