This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane
(PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

At least five muscarinic receptors genes have been cloned and expressed. Muscarinic
receptors act via activation of G proteins: m1, m3 and m5 muscarinic receptors couple to …

Calcium influx in nonexcitable cells regulates such diverse processes as exocytosis,
contraction, enzyme control, gene regulation, cell proliferation, and apoptosis. The dominant …

Proper control of Ca2+ signaling is mandatory for effective cell migration, which is critical for
embryonic development, wound healing, and cancer metastasis. However, how Ca2+ …

Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Submaximal stimulation with agonists generating inositol 1, 4&trisphosphate(IPa) evokes
cytosolic Ca2+ oscillations in many different cell types. In general, each Ca2+ rise is initiated …