The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …
from a binding site with unknown function to a firmly established major effector within the …
Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1–7)/MasR signaling in normal and hypertensive pregnancy
CR Clark, RA Khalil - Biochemical Pharmacology, 2024 - Elsevier
Abstract Normal pregnancy (Norm-Preg) is associated with a slight reduction in blood
pressure (BP) and decreased BP response to vasoconstrictor stimuli such as angiotensin II …
pressure (BP) and decreased BP response to vasoconstrictor stimuli such as angiotensin II …
Transfer of regulatory T cells into abortion-prone mice promotes the expansion of uterine mast cells and normalizes early pregnancy angiogenesis
K Woidacki, N Meyer, A Schumacher, A Goldschmidt… - Scientific reports, 2015 - nature.com
Implantation of the fertilized egg depends on the coordinated interplay of cells and
molecules that prepare the uterus for this important event. In particular, regulatory T cells …
molecules that prepare the uterus for this important event. In particular, regulatory T cells …
Hypoxia, AMPK activation and uterine artery vasoreactivity
KL Skeffington, JS Higgins, AD Mahmoud… - The Journal of …, 2016 - Wiley Online Library
Key points Uterine artery vasodilatation is a key mechanism for increasing utero‐placental
blood flow and fetal nutrient supply. Since the pioneering work of Joseph Barcroft, the …
blood flow and fetal nutrient supply. Since the pioneering work of Joseph Barcroft, the …
AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy
The hemodynamic and nonhemodynamic effects of angiotensin II on diabetic complications
are considered to be primarily mediated by the angiotensin II type 1 receptor subtype …
are considered to be primarily mediated by the angiotensin II type 1 receptor subtype …
Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure
The angiotensin type 2 receptor (AT2R) and the receptor MAS are receptors within the renin–
angiotensin system, which mediate tissue-protective actions such as anti-inflammation …
angiotensin system, which mediate tissue-protective actions such as anti-inflammation …
Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity
Angiotensin-converting enzyme 2 (ACE2) knockout is associated with reduced fetal weight
at late gestation; however, whether uteroplacental vascular and/or hemodynamic …
at late gestation; however, whether uteroplacental vascular and/or hemodynamic …
The renin-angiotensin system in hypertension, a constantly renewing classic: focus on the angiotensin AT2-receptor
It is common knowledge that the renin-angiotensin system (RAS), in particular angiotensin II
acting through the angiotensin AT 1-receptor (AT 1 R), is pivotal for the regulation of blood …
acting through the angiotensin AT 1-receptor (AT 1 R), is pivotal for the regulation of blood …
Pregnancy upregulates angiotensin type 2 receptor expression and increases blood flow in uterine arteries of rats
Normal pregnancy is associated with decreased uterine vascular contraction and increased
blood flow even though angiotensin II (AngII) levels are increased. AngII not only activates …
blood flow even though angiotensin II (AngII) levels are increased. AngII not only activates …
Acute intravenous exposure to silver nanoparticles during pregnancy induces particle size and vehicle dependent changes in vascular tissue contractility in Sprague …
The use of silver nanoparticles (AgNP) raises safety concerns during susceptible life stages
such as pregnancy. We hypothesized that acute intravenous exposure to AgNP during late …
such as pregnancy. We hypothesized that acute intravenous exposure to AgNP during late …