Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). Fatty
liver promotes liver metastasis, but the underlying mechanism remains unclear. We …

Hyperactivation of YAP/TAZ, the Hippo pathway downstream effectors, is common in human
cancer. The requirement of YAP/TAZ for cancer cell survival in preclinical models, prompted …

The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …

Tumor Treating Fields (TTFields), an approved therapy for glioblastoma (GBM) and
malignant mesothelioma, employ noninvasive application of low-intensity, intermediate …

Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …

Lung cancer is the most malignant human cancer worldwide, also with the highest incidence
rate. However, small-cell lung cancer (SCLC) accounts for 14% of all lung cancer cases …

Simple Summary YAP/TAZ are the central effectors of the Hippo pathway and orchestrate
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …

Cancer initiation and progression drastically alter the microenvironment at the interface
between healthy and malignant tissue. This site, termed the peritumor, bears unique …