This two‐part Review examines how automation has contributed to different aspects of
discovery in the chemical sciences. In this first part, we describe a classification for …

Although extending the reactivity of a given class of molecules is relatively straightforward,
the discovery of genuinely new reactivity and the molecules that result is a wholly more …

We present a reference, comprehensive, high-resolution, digital mosaic of ice motion in
Antarctica assembled from multiple satellite interferometric synthetic-aperture radar data …

Serendipity has long been a welcome yet elusive phenomenon in the advancement of
chemistry. We sought to exploit serendipity as a means of rapidly identifying unanticipated …

Compounds consisting of a carbonyl group and an alkyne group, especially enynals and
enynones, are versatile and powerful building blocks for generating structurally diverse …

Synthetic chemists are constantly challenged to consider more environmentally benign
methods for generation of the desired target molecules. 1 Recently, there has been an …

Direct and rapid heating by microwave irradiation in combination with sealed vessel
processing in many cases enables reactions to be carried out in a fraction of the time …

An automated, droplet-flow microfluidic system explores and optimizes Pd-catalyzed Suzuki–
Miyaura cross-coupling reactions. A smart optimal DoE-based algorithm is implemented to …

Homogeneous catalysis has provided chemists with numerous transformations to enable
rapid construction of organic molecules. However, these reactions are complex, requiring …

Green chemistry and flow chemistry are ideal partners for accessing novel chemical spaces
and define highly efficient synthetic tools. In this review article contributions have been …