Main components of fish immunity: An overview of the fish immune system
DM Mokhtar, G Zaccone, A Alesci, M Kuciel… - Fishes, 2023 - mdpi.com
Cellular immune responses consist of innate and adaptive cell-mediated immune
mechanisms, where all leukocyte subpopulations are included. Among these are vital …
mechanisms, where all leukocyte subpopulations are included. Among these are vital …
Host genetics and infectious disease: new tools, insights and translational opportunities
Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
Host–parasite co-evolution and its genomic signature
Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
Inferring balancing selection from genome-scale data
The identification of genomic regions and genes that have evolved under natural selection is
a fundamental objective in the field of evolutionary genetics. While various approaches have …
a fundamental objective in the field of evolutionary genetics. While various approaches have …
Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond
Structural and functional variability of human leukocyte antigen (HLA) is the foundation for
competent adaptive immune responses against pathogen and tumor antigens as it assures …
competent adaptive immune responses against pathogen and tumor antigens as it assures …
Earliest modern human genomes constrain timing of Neanderthal admixture
Modern humans arrived in Europe more than 45,000 years ago, overlap** at least 5,000
years with Neanderthals 1, 2, 3, 4. Limited genomic data from these early modern humans …
years with Neanderthals 1, 2, 3, 4. Limited genomic data from these early modern humans …
Complete sequencing of ape genomes
We present haplotype-resolved reference genomes and comparative analyses of six ape
species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan …
species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan …
Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease
The human leukocyte antigen (HLA) locus is associated with more complex diseases than
any other locus in the human genome. In many diseases, HLA explains more heritability …
any other locus in the human genome. In many diseases, HLA explains more heritability …
Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression
Human leukocyte antigen (HLA) class I and II loci are essential elements of innate and
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …
Widespread adaptive introgression of major histocompatibility complex genes across vertebrate hybrid zones
T Gaczorek, K Dudek, U Fritz… - Molecular Biology …, 2024 - academic.oup.com
Interspecific introgression is a potentially important source of novel variation of adaptive
significance. Although multiple cases of adaptive introgression are well documented …
significance. Although multiple cases of adaptive introgression are well documented …