Immunotherapy has emerged as a promising cancer treatment modality. Despite the rapid
progress in cancer immunotherapy, the therapeutic efficiency and clinical translation of …

Necroptosis | New England Journal of Medicine Skip to main content The New England Journal
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Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Chemotherapy has been a conventional paradigm for cancer treatment, and multifarious
chemotherapeutic drugs have been widely employed for decades with significant …

The term “immunogenic cell death”(ICD) is now employed to indicate a functionally peculiar
form of apoptosis that is sufficient for immunocompetent hosts to mount an adaptive immune …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Background Develo** the ability to use tumor-directed therapies to trigger potentially
therapeutic immune responses against cancer antigens remains a high priority for cancer …

Immunogenic cell death induced by anticancer chemotherapy is characterized by a series of
molecular hallmarks that include the exodus of high-mobility group box 1 protein (HMGB1) …

Introduction Histotripsy is a novel focused ultrasound tumor ablation modality with potent
immunostimulatory effects. Methods To measure the spatiotemporal kinetics of local …

Upon solid organ transplantation and during cancer immunotherapy, cellular stress
responses result in the release of damage-associated molecular patterns (DAMPs). The …